TIE1


Summary: This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tyrosine kinase with immunoglobulin like and EGF like domains 1MIM:600222Ensembl:ENSG00000066056HGNC:HGNC:11809PA365161p34.2

GO terms in TIE1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIEAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
CCIBAGO:0005737cytoplasm
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIBAGO:0043235receptor complex
BPIEAGO:0001525angiogenesis
BPIEAGO:0001570vasculogenesis
BPIEAGO:0001701in utero embryonic development
BPTASGO:0007165signal transduction
BPIBAGO:0007275multicellular organism development
BPTASGO:0007498mesoderm development
BPIBAGO:0009968negative regulation of signal transduction
BPIEAGO:0016525negative regulation of angiogenesis
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0030154cell differentiation
BPIEAGO:0030336negative regulation of cell migration
BPIEAGO:0032526response to retinoic acid
BPIBAGO:0033674positive regulation of kinase activity
BPIBAGO:0043066negative regulation of apoptotic process
BPIBAGO:0043410positive regulation of MAPK cascade
BPIEAGO:0045026plasma membrane fusion
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade

Gene expression in normal tissue: TIE1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TIE1


DatabasePathway IDPathway Des.
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD506Fedratinib3
iGMDRD780PP-302
iGMDRD188Piperlongumine6
iGMDRD399Selumetinib3
iGMDRD23Gossypol3
iGMDRD356PNU-746542
iGMDRD524ISX-94
iGMDRD64Parbendazole5
iGMDRD260FQI-22
iGMDRD52Rotenone2
iGMDRD187BRD98765
iGMDRD171Pemetrexed5
iGMDRD61Kinetin riboside2
iGMDRD466Chaetocin3
iGMDRD394BX-7953
iGMDRD889Compound 7d-cis3
iGMDRD126Tipifarnib3
iGMDRD151CHM-12
iGMDRD433Lexibulin2
iGMDRD483SCH-5290743
iGMDRD781Sirolimus3
iGMDRD546BMS-7548073
iGMDRD779PRL-3 Inhibitor I2
iGMDRD329Merck605
iGMDRD871BRD63682
iGMDRD286Nsc 6328392
iGMDRD322FK 8661
iGMDRD103SN-382
iGMDRD121GMX17782
iGMDRD158NSC1415404
iGMDRD202Curcumin2
iGMDRD137Indisulam2
iGMDRD289Parthenolide2
iGMDRD237ABT-7515
iGMDRD154NSC237662
iGMDRD945ML2143
iGMDRD123Isoevodiamine4
iGMDRD584VER 1550081
iGMDRD330BRD41326
iGMDRD523Cyanoquinoline, 113
iGMDRD79Gemcitabine6
iGMDRD150RITA3
iGMDRD560MK-22062
iGMDRD577BIX012943
iGMDRD100Zebularine2
iGMDRD268Cerulenin3
iGMDRD451Serdemetan2
iGMDRD60Quinoclamine1
iGMDRD138PX 123
iGMDRD885Compound 1104
iGMDRD870BRD636103
iGMDRD193Fqi15
iGMDRD446LY 21832401
iGMDRD634SCHEMBL26080413
iGMDRD359OSW-11
iGMDRD280CYTOCHALASIN B2
iGMDRD599Salermide5
iGMDRD772BRD47702
iGMDRD1008SR-II-138A5
iGMDRD494Neopeltolide3
iGMDRD144NSC953972
iGMDRD414MST-3122
iGMDRD42Vorinostat2
iGMDRD505Pevonedistat2
iGMDRD246NPC264
iGMDRD415LE-1352
iGMDRD481Dactolisib3
iGMDRD267Oligomycin A1
iGMDRD434BMS-5369242
iGMDRD351GW843682X2
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD177Teniposide6
iGMDRD512nutlin 32
iGMDRD607Ubistatin B2
iGMDRD424Tamatinib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TIE1

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