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BRCA2

Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
BRCA2, DNA repair associated	MIM:600185	Ensembl:ENSG00000139618	HGNC:HGNC:1101	PA25412	13q13.1

Gene Categories:

HISTONE MODIFICATION CLINICALLY ACTIONABLE TUMOR SUPPRESSOR DNA REPAIR

GO terms in BRCA2

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0002020	protease binding
MF	IPI	GO:0002020	protease binding
MF	IBA	GO:0003697	single-stranded DNA binding
MF	IDA	GO:0003697	single-stranded DNA binding
MF	IBA	GO:0004402	histone acetyltransferase activity
MF	IDA	GO:0004402	histone acetyltransferase activity
MF	IBA	GO:0005515	protein binding
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0008022	protein C-terminus binding
MF	IDA	GO:0008022	protein C-terminus binding
MF	IDA	GO:0010484	H3 histone acetyltransferase activity
MF	IDA	GO:0010485	H4 histone acetyltransferase activity
MF	IBA	GO:0042802	identical protein binding
MF	IPI	GO:0042802	identical protein binding
MF	IBA	GO:0043015	gamma-tubulin binding
MF	IPI	GO:0043015	gamma-tubulin binding
CC	IBA	GO:0000784	nuclear chromosome, telomeric region
CC	IDA	GO:0000784	nuclear chromosome, telomeric region
CC	IBA	GO:0000800	lateral element
CC	IDA	GO:0000800	lateral element
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	IBA	GO:0005654	nucleoplasm
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IBA	GO:0005813	centrosome
CC	IDA	GO:0005813	centrosome
CC	IBA	GO:0005829	cytosol
CC	IDA	GO:0005829	cytosol
CC	IBA	GO:0030141	secretory granule
CC	IDA	GO:0030141	secretory granule
CC	IDA	GO:0032991	protein-containing complex
CC	IBA	GO:0033593	BRCA2-MAGE-D1 complex
CC	IDA	GO:0033593	BRCA2-MAGE-D1 complex
BP	IDA	GO:0000281	mitotic cytokinesis
BP	IBA	GO:0000722	telomere maintenance via recombination
BP	IEA	GO:0000722	telomere maintenance via recombination
BP	IBA	GO:0000724	double-strand break repair via homologous recombination
BP	IDA	GO:0000724	double-strand break repair via homologous recombination
BP	IMP	GO:0000724	double-strand break repair via homologous recombination
BP	IBA	GO:0001556	oocyte maturation
BP	IEA	GO:0001556	oocyte maturation
BP	IBA	GO:0001833	inner cell mass cell proliferation
BP	IEA	GO:0001833	inner cell mass cell proliferation
BP	IBA	GO:0006289	nucleotide-excision repair
BP	IMP	GO:0006289	nucleotide-excision repair
BP	IMP	GO:0006302	double-strand break repair
BP	IBA	GO:0006355	regulation of transcription, DNA-templated
BP	IBA	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
BP	IEA	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
BP	IBA	GO:0007141	male meiosis I
BP	IEA	GO:0007141	male meiosis I
BP	IBA	GO:0007283	spermatogenesis
BP	IEA	GO:0007283	spermatogenesis
BP	IBA	GO:0007420	brain development
BP	IEA	GO:0007420	brain development
BP	IEA	GO:0007569	cell aging
BP	IBA	GO:0007584	response to nutrient
BP	IBA	GO:0008585	female gonad development
BP	IEA	GO:0008585	female gonad development
BP	IBA	GO:0010165	response to X-ray
BP	IEA	GO:0010165	response to X-ray
BP	IBA	GO:0010225	response to UV-C
BP	IEA	GO:0010225	response to UV-C
BP	IBA	GO:0010332	response to gamma radiation
BP	IEA	GO:0010332	response to gamma radiation
BP	IBA	GO:0010778	meiotic DNA repair synthesis involved in reciprocal meiotic recombination
BP	IBA	GO:0030097	hemopoiesis
BP	IEA	GO:0030097	hemopoiesis
BP	IBA	GO:0030879	mammary gland development
BP	IBA	GO:0031619	homologous chromosome orientation involved in meiotic metaphase I plate congression
BP	IBA	GO:0032355	response to estradiol
BP	IBA	GO:0032465	regulation of cytokinesis
BP	IEA	GO:0032465	regulation of cytokinesis
BP	IBA	GO:0033600	negative regulation of mammary gland epithelial cell proliferation
BP	IDA	GO:0033600	negative regulation of mammary gland epithelial cell proliferation
BP	IBA	GO:0035264	multicellular organism growth
BP	IBA	GO:0042127	regulation of cell proliferation
BP	IBA	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BP	IEA	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BP	IBA	GO:0043150	DNA synthesis involved in double-strand break repair via homologous recombination
BP	IBA	GO:0043966	histone H3 acetylation
BP	IDA	GO:0043966	histone H3 acetylation
BP	IBA	GO:0043967	histone H4 acetylation
BP	IDA	GO:0043967	histone H4 acetylation
BP	IBA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IBA	GO:0045931	positive regulation of mitotic cell cycle
BP	IEA	GO:0045931	positive regulation of mitotic cell cycle
BP	IBA	GO:0048478	replication fork protection
BP	IEA	GO:0048478	replication fork protection
BP	IBA	GO:0051298	centrosome duplication
BP	IMP	GO:0051298	centrosome duplication
BP	IBA	GO:0051598	meiotic recombination checkpoint
BP	IBA	GO:0070200	establishment of protein localization to telomere
BP	IDA	GO:0070200	establishment of protein localization to telomere
BP	IBA	GO:1990426	mitotic recombination-dependent replication fork processing
BP	IMP	GO:1990426	mitotic recombination-dependent replication fork processing

Gene expression in normal tissue: BRCA2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BRCA2

Database	Pathway ID	Pathway Des.
wikipathways	WP186	Homologous recombination
wikipathways	WP1984	Integrated Breast Cancer Pathway
wikipathways	WP2261	Signaling Pathways in Glioblastoma
pid	atr_pathway	ATR signaling pathway
pid	deltanp63pathway	Validated transcriptional targets of deltaNp63 isoforms
pid	fanconi_pathway	Fanconi anemia pathway
pid	foxm1pathway	FOXM1 transcription factor network
pid	p73pathway	p73 transcription factor network
kegg	hsa03440	Homologous recombination - Homo sapiens (human)
kegg	hsa03460	Fanconi anemia pathway - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05212	Pancreatic cancer - Homo sapiens (human)
kegg	hsa05224	Breast cancer - Homo sapiens (human)
biocarta	atrbrcapathway	role of brca1 brca2 and atr in cancer susceptibility
reactome	R-HSA-1474165	Reproduction
reactome	R-HSA-1500620	Meiosis
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-5685942	HDR through Homologous Recombination (HRR)
reactome	R-HSA-5693532	DNA Double-Strand Break Repair
reactome	R-HSA-5693537	Resolution of D-Loop Structures
reactome	R-HSA-5693538	Homology Directed Repair
reactome	R-HSA-5693554	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
reactome	R-HSA-5693567	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactome	R-HSA-5693568	Resolution of D-loop Structures through Holliday Junction Intermediates
reactome	R-HSA-5693579	Homologous DNA Pairing and Strand Exchange
reactome	R-HSA-5693616	Presynaptic phase of homologous DNA pairing and strand exchange
reactome	R-HSA-73894	DNA Repair
reactome	R-HSA-912446	Meiotic recombination

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD151	CHM-1	7
iGMDRD433	Lexibulin	4
iGMDRD76	Simvastatin	2
iGMDRD126	Tipifarnib	3
iGMDRD420	Leucascandrolide A	6
iGMDRD889	Compound 7d-cis	3
iGMDRD670	ML 210	3
iGMDRD779	PRL-3 Inhibitor I	2
iGMDRD974	PD1 blockade	1
iGMDRD639	YK 4-279	4
iGMDRD466	Chaetocin	4
iGMDRD260	FQI-2	7
iGMDRD171	Pemetrexed	2
iGMDRD187	BRD9876	3
iGMDRD399	Selumetinib	2
iGMDRD74	Idarubicin	2
iGMDRD188	Piperlongumine	4
iGMDRD146	Elesclomol	1
iGMDRD190	Nilotinib	1
iGMDRD64	Parbendazole	3
iGMDRD369	TGX-115	2
iGMDRD23	Gossypol	3
iGMDRD532	Olaparib	18
iGMDRD150	RITA	4
iGMDRD405	PIK-75	2
iGMDRD583	LDN 193189	1
iGMDRD50	Cytarabine	1
iGMDRD49	Mitomycin	1
iGMDRD341	Triacsin c	1
iGMDRD237	ABT-751	6
iGMDRD383	Cediranib	1
iGMDRD123	Isoevodiamine	6
iGMDRD879	chemotherapy	4
iGMDRD945	ML214	4
iGMDRD883	CIL55A	2
iGMDRD154	NSC23766	2
iGMDRD137	Indisulam	7
iGMDRD121	GMX1778	2
iGMDRD103	SN-38	4
iGMDRD402	AKT Inhibitor VIII	1
iGMDRD288	Carboplatin	1
iGMDRD289	Parthenolide	2
iGMDRD705	Nakiterpiosin	8
iGMDRD105	Triptolide	1
iGMDRD871	BRD6368	1
iGMDRD286	Nsc 632839	6
iGMDRD552	AZD-1775	2
iGMDRD263	AACOCF3	3
iGMDRD1008	SR-II-138A	2
iGMDRD387	CHIR-99021	3
iGMDRD971	PARP inhibitor	7
iGMDRD494	Neopeltolide	2
iGMDRD462	OSI-906 (Linsitinib)	1
iGMDRD446	LY 2183240	3
iGMDRD193	Fqi1	4
iGMDRD280	CYTOCHALASIN B	1
iGMDRD401	Afatinib	1
iGMDRD138	PX 12	5
iGMDRD109	Gefitinib	1
iGMDRD255	SB225002	2
iGMDRD802	4-methylfasudil	3
iGMDRD782	DC-45-A2	2
iGMDRD973	PD1 Ab inhibitor	1
iGMDRD309	17AAG	1
iGMDRD441	TW 37	3
iGMDRD100	Zebularine	3
iGMDRD577	BIX01294	2
iGMDRD411	Platinum Agent	7
iGMDRD451	Serdemetan	4
iGMDRD486	Tosedostat	2
iGMDRD512	nutlin 3	3
iGMDRD299	ICL 670	1
iGMDRD160	Cis-Platin	3
iGMDRD345	Compound 10b [PMID: 11504634]	3
iGMDRD536	PLX-4720	1
iGMDRD351	GW843682X	7
iGMDRD901	ELCPK	3
iGMDRD211	(1S,3R)-RSL3	3
iGMDRD435	BI-2536	2
iGMDRD479	Veliparib	2
iGMDRD434	BMS-536924	8
iGMDRD62	Platinum	2
iGMDRD381	Rucaparib	2
iGMDRD504	Obatoclax	1
iGMDRD872	BRD7137	1
iGMDRD414	MST-312	1
iGMDRD246	NPC26	3
iGMDRD505	Pevonedistat	6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BRCA2

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.