SERPINA2
Summary: This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. The encoded intracellular glycoprotein is localized at the endoplasmic reticulum. This gene is a polymorphic pseudogene, with the non-functional allele being predominant in some populations. Some individuals, as represented by the reference genome allele, contain a 2kb coding region deletion and a start code mutation. [provided by RefSeq, Feb 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
serpin family A member 2 (gene/pseudogene) | MIM:107410 | Ensembl:ENSG00000258597 | HGNC:HGNC:8985 | PA35520 | 14q32.13 |
GO terms in SERPINA2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IBA | GO:0005615 | extracellular space |
CC | IDA | GO:0005783 | endoplasmic reticulum |
BP | IBA | GO:0010951 | negative regulation of endopeptidase activity |
BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
MF | IBA | GO:0004867 | serine-type endopeptidase inhibitor activity |
MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: SERPINA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SERPINA2
Database | Pathway ID | Pathway Des. |
---|
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD414 | MST-312 | 3 |
iGMDRD882 | CIL41 | 2 |
iGMDRD246 | NPC26 | 2 |
iGMDRD42 | Vorinostat | 4 |
iGMDRD384 | EHT-1864 | 1 |
iGMDRD434 | BMS-536924 | 1 |
iGMDRD504 | Obatoclax | 1 |
iGMDRD389 | SB525334 | 1 |
iGMDRD85 | Ursolic acid | 4 |
iGMDRD57 | Chloropentafluorobenzene | 2 |
iGMDRD901 | ELCPK | 3 |
iGMDRD177 | Teniposide | 3 |
iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
iGMDRD382 | CEP-701 | 1 |
iGMDRD307 | Manumycin A | 3 |
iGMDRD486 | Tosedostat | 3 |
iGMDRD512 | nutlin 3 | 3 |
iGMDRD100 | Zebularine | 4 |
iGMDRD887 | Compound 23 citrate | 1 |
iGMDRD185 | DMOG | 1 |
iGMDRD562 | Navitoclax | 2 |
iGMDRD291 | AC1NS4S0 | 1 |
iGMDRD451 | Serdemetan | 4 |
iGMDRD138 | PX 12 | 4 |
iGMDRD870 | BRD63610 | 2 |
iGMDRD446 | LY 2183240 | 3 |
iGMDRD253 | Vincaleukoblastine | 1 |
iGMDRD686 | PF4708671 | 1 |
iGMDRD281 | Vinorelbine base | 1 |
iGMDRD193 | Fqi1 | 1 |
iGMDRD280 | CYTOCHALASIN B | 3 |
iGMDRD599 | Salermide | 5 |
iGMDRD1008 | SR-II-138A | 3 |
iGMDRD772 | BRD4770 | 3 |
iGMDRD144 | NSC95397 | 2 |
iGMDRD587 | CHEMBL585951 | 1 |
iGMDRD494 | Neopeltolide | 2 |
iGMDRD971 | PARP inhibitor | 1 |
iGMDRD354 | Midostaurin | 1 |
iGMDRD871 | BRD6368 | 1 |
iGMDRD286 | Nsc 632839 | 3 |
iGMDRD662 | JQ-1 | 2 |
iGMDRD329 | Merck60 | 1 |
iGMDRD552 | AZD-1775 | 2 |
iGMDRD263 | AACOCF3 | 2 |
iGMDRD421 | AZD7762 | 2 |
iGMDRD322 | FK 866 | 2 |
iGMDRD173 | Epothilone B | 1 |
iGMDRD137 | Indisulam | 5 |
iGMDRD293 | Bleomycin | 1 |
iGMDRD158 | NSC141540 | 3 |
iGMDRD121 | GMX1778 | 4 |
iGMDRD202 | Curcumin | 4 |
iGMDRD5 | Tyrphostin AG 1478 | 5 |
iGMDRD215 | CCT007093 | 1 |
iGMDRD289 | Parthenolide | 5 |
iGMDRD105 | Triptolide | 2 |
iGMDRD705 | Nakiterpiosin | 2 |
iGMDRD77 | Itraconazole | 2 |
iGMDRD341 | Triacsin c | 6 |
iGMDRD49 | Mitomycin | 1 |
iGMDRD123 | Isoevodiamine | 3 |
iGMDRD511 | CHEMBL399379 | 3 |
iGMDRD945 | ML214 | 7 |
iGMDRD584 | VER 155008 | 2 |
iGMDRD150 | RITA | 7 |
iGMDRD532 | Olaparib | 4 |
iGMDRD594 | AZD-8055 | 1 |
iGMDRD79 | Gemcitabine | 4 |
iGMDRD188 | Piperlongumine | 8 |
iGMDRD74 | Idarubicin | 2 |
iGMDRD399 | Selumetinib | 2 |
iGMDRD888 | Compound 44 | 6 |
iGMDRD780 | PP-30 | 6 |
iGMDRD64 | Parbendazole | 3 |
iGMDRD23 | Gossypol | 3 |
iGMDRD260 | FQI-2 | 2 |
iGMDRD44 | Temozolomide | 2 |
iGMDRD187 | BRD9876 | 5 |
iGMDRD52 | Rotenone | 2 |
iGMDRD61 | Kinetin riboside | 5 |
iGMDRD466 | Chaetocin | 6 |
iGMDRD126 | Tipifarnib | 4 |
iGMDRD433 | Lexibulin | 3 |
iGMDRD889 | Compound 7d-cis | 2 |
iGMDRD420 | Leucascandrolide A | 2 |
iGMDRD856 | BRD-K66532283 | 1 |
iGMDRD427 | ABT737 | 3 |
iGMDRD483 | SCH-529074 | 3 |
iGMDRD781 | Sirolimus | 8 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SERPINA2