SERPINA2


Summary: This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. The encoded intracellular glycoprotein is localized at the endoplasmic reticulum. This gene is a polymorphic pseudogene, with the non-functional allele being predominant in some populations. Some individuals, as represented by the reference genome allele, contain a 2kb coding region deletion and a start code mutation. [provided by RefSeq, Feb 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
serpin family A member 2 (gene/pseudogene)MIM:107410Ensembl:ENSG00000258597HGNC:HGNC:8985PA3552014q32.13

GO terms in SERPINA2


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005615extracellular space
CCIDAGO:0005783endoplasmic reticulum
BPIBAGO:0010951negative regulation of endopeptidase activity
BPIEAGO:0010951negative regulation of endopeptidase activity
MFIBAGO:0004867serine-type endopeptidase inhibitor activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: SERPINA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SERPINA2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD414MST-3123
iGMDRD882CIL412
iGMDRD246NPC262
iGMDRD42Vorinostat4
iGMDRD384EHT-18641
iGMDRD434BMS-5369241
iGMDRD504Obatoclax1
iGMDRD389SB5253341
iGMDRD85Ursolic acid4
iGMDRD57Chloropentafluorobenzene2
iGMDRD901ELCPK3
iGMDRD177Teniposide3
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD382CEP-7011
iGMDRD307Manumycin A3
iGMDRD486Tosedostat3
iGMDRD512nutlin 33
iGMDRD100Zebularine4
iGMDRD887Compound 23 citrate1
iGMDRD185DMOG1
iGMDRD562Navitoclax2
iGMDRD291AC1NS4S01
iGMDRD451Serdemetan4
iGMDRD138PX 124
iGMDRD870BRD636102
iGMDRD446LY 21832403
iGMDRD253Vincaleukoblastine1
iGMDRD686PF47086711
iGMDRD281Vinorelbine base1
iGMDRD193Fqi11
iGMDRD280CYTOCHALASIN B3
iGMDRD599Salermide5
iGMDRD1008SR-II-138A3
iGMDRD772BRD47703
iGMDRD144NSC953972
iGMDRD587CHEMBL5859511
iGMDRD494Neopeltolide2
iGMDRD971PARP inhibitor1
iGMDRD354Midostaurin1
iGMDRD871BRD63681
iGMDRD286Nsc 6328393
iGMDRD662JQ-12
iGMDRD329Merck601
iGMDRD552AZD-17752
iGMDRD263AACOCF32
iGMDRD421AZD77622
iGMDRD322FK 8662
iGMDRD173Epothilone B1
iGMDRD137Indisulam5
iGMDRD293Bleomycin1
iGMDRD158NSC1415403
iGMDRD121GMX17784
iGMDRD202Curcumin4
iGMDRD5Tyrphostin AG 14785
iGMDRD215CCT0070931
iGMDRD289Parthenolide5
iGMDRD105Triptolide2
iGMDRD705Nakiterpiosin2
iGMDRD77Itraconazole2
iGMDRD341Triacsin c6
iGMDRD49Mitomycin1
iGMDRD123Isoevodiamine3
iGMDRD511CHEMBL3993793
iGMDRD945ML2147
iGMDRD584VER 1550082
iGMDRD150RITA7
iGMDRD532Olaparib4
iGMDRD594AZD-80551
iGMDRD79Gemcitabine4
iGMDRD188Piperlongumine8
iGMDRD74Idarubicin2
iGMDRD399Selumetinib2
iGMDRD888Compound 446
iGMDRD780PP-306
iGMDRD64Parbendazole3
iGMDRD23Gossypol3
iGMDRD260FQI-22
iGMDRD44Temozolomide2
iGMDRD187BRD98765
iGMDRD52Rotenone2
iGMDRD61Kinetin riboside5
iGMDRD466Chaetocin6
iGMDRD126Tipifarnib4
iGMDRD433Lexibulin3
iGMDRD889Compound 7d-cis2
iGMDRD420Leucascandrolide A2
iGMDRD856BRD-K665322831
iGMDRD427ABT7373
iGMDRD483SCH-5290743
iGMDRD781Sirolimus8

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SERPINA2

​​​​