CTNNB1


Summary: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
catenin beta 1MIM:116806Ensembl:ENSG00000168036HGNC:HGNC:2514PA270133p22.1

GO terms in CTNNB1


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000922spindle pole
CCIDAGO:0005622intracellular
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005667transcription factor complex
CCIDAGO:0005719nuclear euchromatin
CCIDAGO:0005737cytoplasm
CCIDAGO:0005813centrosome
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIDAGO:0005911cell-cell junction
CCIDAGO:0005912adherens junction
CCIBAGO:0005913cell-cell adherens junction
CCIDAGO:0005913cell-cell adherens junction
CCIEAGO:0005916fascia adherens
CCIEAGO:0005923bicellular tight junction
CCHDAGO:0005925focal adhesion
CCIDAGO:0005938cell cortex
CCISSGO:0016020membrane
CCIDAGO:0016323basolateral plasma membrane
CCIDAGO:0016328lateral plasma membrane
CCIBAGO:0016342catenin complex
CCIDAGO:0016342catenin complex
CCIEAGO:0016600flotillin complex
CCIEAGO:0030018Z disc
CCIEAGO:0030027lamellipodium
CCIDAGO:0030054cell junction
CCTASGO:0030054cell junction
CCIDAGO:0030877beta-catenin destruction complex
CCIEAGO:0031528microvillus membrane
CCIDAGO:0032991protein-containing complex
CCIDAGO:0032993protein-DNA complex
CCIEAGO:0034750Scrib-APC-beta-catenin complex
CCIEAGO:0045177apical part of cell
CCISSGO:0045202synapse
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
CCIDAGO:0070369beta-catenin-TCF7L2 complex
CCIDAGO:0071944cell periphery
CCIDAGO:1990907beta-catenin-TCF complex
CCIPIGO:1990907beta-catenin-TCF complex
CCNASGO:1990909Wnt signalosome
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0000578embryonic axis specification
BPIEAGO:0000904cell morphogenesis involved in differentiation
BPICGO:0001569branching involved in blood vessel morphogenesis
BPIEAGO:0001658branching involved in ureteric bud morphogenesis
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0001702gastrulation with mouth forming second
BPIEAGO:0001708cell fate specification
BPIEAGO:0001711endodermal cell fate commitment
BPIEAGO:0001764neuron migration
BPTASGO:0001837epithelial to mesenchymal transition
BPIEAGO:0001840neural plate development
BPISSGO:0002052positive regulation of neuroblast proliferation
BPIEAGO:0002053positive regulation of mesenchymal cell proliferation
BPIEAGO:0002089lens morphogenesis in camera-type eye
BPIEAGO:0003266regulation of secondary heart field cardioblast proliferation
BPIEAGO:0003338metanephros morphogenesis
BPIEAGO:0003340negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
BPIEAGO:0006351transcription, DNA-templated
BPIMPGO:0007155cell adhesion
BPIEAGO:0007160cell-matrix adhesion
BPTASGO:0007223Wnt signaling pathway, calcium modulating pathway
BPIEAGO:0007268chemical synaptic transmission
BPIEAGO:0007398ectoderm development
BPIEAGO:0007403glial cell fate determination
BPIDAGO:0008285negative regulation of cell proliferation
BPIEAGO:0009948anterior/posterior axis specification
BPIEAGO:0009950dorsal/ventral axis specification
BPIEAGO:0009954proximal/distal pattern formation
BPIGIGO:0010718positive regulation of epithelial to mesenchymal transition
BPIMPGO:0010909positive regulation of heparan sulfate proteoglycan biosynthetic process
BPTASGO:0016055Wnt signaling pathway
BPISSGO:0016525negative regulation of angiogenesis
BPTASGO:0019827stem cell population maintenance
BPIEAGO:0021819layer formation in cerebral cortex
BPIEAGO:0022009central nervous system vasculogenesis
BPIEAGO:0030316osteoclast differentiation
BPNASGO:0030521androgen receptor signaling pathway
BPIEAGO:0030539male genitalia development
BPIEAGO:0030902hindbrain development
BPIDAGO:0030997regulation of centriole-centriole cohesion
BPIEAGO:0031016pancreas development
BPIEAGO:0031069hair follicle morphogenesis
BPIEAGO:0031641regulation of myelination
BPIEAGO:0032212positive regulation of telomere maintenance via telomerase
BPIEAGO:0032331negative regulation of chondrocyte differentiation
BPIDAGO:0032355response to estradiol
BPTASGO:0032481positive regulation of type I interferon production
BPIEAGO:0033077T cell differentiation in thymus
BPIDAGO:0033234negative regulation of protein sumoylation
BPIMPGO:0034333adherens junction assembly
BPIMPGO:0034394protein localization to cell surface
BPIEAGO:0035050embryonic heart tube development
BPIEAGO:0035112genitalia morphogenesis
BPIEAGO:0035115embryonic forelimb morphogenesis
BPIEAGO:0035116embryonic hindlimb morphogenesis
BPTASGO:0035315hair cell differentiation
BPTASGO:0035635entry of bacterium into host cell
BPISSGO:0036023embryonic skeletal limb joint morphogenesis
BPIEAGO:0042129regulation of T cell proliferation
BPIEAGO:0042475odontogenesis of dentin-containing tooth
BPIEPGO:0042493response to drug
BPIEAGO:0042733embryonic digit morphogenesis
BPIDAGO:0043065positive regulation of apoptotic process
BPIEAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043410positive regulation of MAPK cascade
BPIDAGO:0043525positive regulation of neuron apoptotic process
BPIMPGO:0044334canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
BPIMPGO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process
BPTASGO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process
BPIEAGO:0045453bone resorption
BPIEAGO:0045603positive regulation of endothelial cell differentiation
BPIEAGO:0045669positive regulation of osteoblast differentiation
BPIEAGO:0045671negative regulation of osteoclast differentiation
BPIEAGO:0045743positive regulation of fibroblast growth factor receptor signaling pathway
BPTASGO:0045765regulation of angiogenesis
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPTASGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0045976negative regulation of mitotic cell cycle, embryonic
BPIEAGO:0048096chromatin-mediated maintenance of transcription
BPTASGO:0048145regulation of fibroblast proliferation
BPIEAGO:0048469cell maturation
BPIEAGO:0048489synaptic vesicle transport
BPIEAGO:0048538thymus development
BPIEAGO:0048599oocyte development
BPIEAGO:0048617embryonic foregut morphogenesis
BPIEAGO:0048643positive regulation of skeletal muscle tissue development
BPIMPGO:0048660regulation of smooth muscle cell proliferation
BPIEAGO:0048715negative regulation of oligodendrocyte differentiation
BPTASGO:0050767regulation of neurogenesis
BPIEAGO:0050808synapse organization
BPIMPGO:0051091positive regulation of DNA-binding transcription factor activity
BPIEAGO:0051145smooth muscle cell differentiation
BPTASGO:0051149positive regulation of muscle cell differentiation
BPICGO:0051571positive regulation of histone H3-K4 methylation
BPIEAGO:0051884regulation of timing of anagen
BPIEAGO:0051973positive regulation of telomerase activity
BPIEAGO:0060066oviduct development
BPIDAGO:0060070canonical Wnt signaling pathway
BPIMPGO:0060070canonical Wnt signaling pathway
BPIEAGO:0060440trachea formation
BPIEAGO:0060441epithelial tube branching involved in lung morphogenesis
BPIEAGO:0060479lung cell differentiation
BPIEAGO:0060484lung-associated mesenchyme development
BPIEAGO:0060492lung induction
BPIEAGO:0060742epithelial cell differentiation involved in prostate gland development
BPIEAGO:0060769positive regulation of epithelial cell proliferation involved in prostate gland development
BPIEAGO:0060789hair follicle placode formation
BPIEAGO:0060916mesenchymal cell proliferation involved in lung development
BPIMPGO:0061154endothelial tube morphogenesis
BPIEAGO:0061198fungiform papilla formation
BPISSGO:0061324canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
BPISSGO:0061549sympathetic ganglion development
BPIEAGO:0061550cranial ganglion development
BPIMPGO:0070602regulation of centromeric sister chromatid cohesion
BPIMPGO:0071363cellular response to growth factor stimulus
BPIDAGO:0071681cellular response to indole-3-methanol
BPIEAGO:0072033renal vesicle formation
BPIEAGO:0072053renal inner medulla development
BPIEAGO:0072054renal outer medulla development
BPIEAGO:0072079nephron tubule formation
BPISSGO:0072182regulation of nephron tubule epithelial cell differentiation
BPIDAGO:0090279regulation of calcium ion import
BPIMPGO:0098609cell-cell adhesion
BPIEAGO:1903204negative regulation of oxidative stress-induced neuron death
BPIEAGO:1904501positive regulation of chromatin-mediated maintenance of transcription
BPIEAGO:1904793regulation of euchromatin binding
BPIDAGO:1904798positive regulation of core promoter binding
BPTASGO:1904837beta-catenin-TCF complex assembly
BPTASGO:1904886beta-catenin destruction complex disassembly
BPIEAGO:1904888cranial skeletal system development
BPISSGO:1904948midbrain dopaminergic neuron differentiation
BPICGO:1904954canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
BPIMPGO:1990138neuron projection extension
BPIEAGO:1990403embryonic brain development
BPIEAGO:1990791dorsal root ganglion development
BPIDAGO:2000008regulation of protein localization to cell surface
BPIEAGO:2000017positive regulation of determination of dorsal identity
BPICGO:2000144positive regulation of DNA-templated transcription, initiation
BPIEAGO:2001234negative regulation of apoptotic signaling pathway
MFIDAGO:0001085RNA polymerase II transcription factor binding
MFIPIGO:0001085RNA polymerase II transcription factor binding
MFIPIGO:0001102RNA polymerase II activating transcription factor binding
MFISSGO:0003682chromatin binding
MFIEAGO:0003700DNA-binding transcription factor activity
MFIBAGO:0003713transcription coactivator activity
MFIDAGO:0003713transcription coactivator activity
MFIMPGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIPIGO:0008022protein C-terminus binding
MFIPIGO:0008134transcription factor binding
MFTASGO:0008134transcription factor binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0019900kinase binding
MFIEAGO:0019901protein kinase binding
MFIBAGO:0019903protein phosphatase binding
MFIPIGO:0019903protein phosphatase binding
MFIPIGO:0030331estrogen receptor binding
MFIBAGO:0035257nuclear hormone receptor binding
MFIPIGO:0035257nuclear hormone receptor binding
MFTASGO:0035257nuclear hormone receptor binding
MFIPIGO:0044325ion channel binding
MFIBAGO:0045294alpha-catenin binding
MFIPIGO:0045294alpha-catenin binding
MFHDAGO:0045296cadherin binding
MFIBAGO:0045296cadherin binding
MFIPIGO:0045296cadherin binding
MFIPIGO:0046332SMAD binding
MFIEAGO:0046982protein heterodimerization activity
MFNASGO:0050681androgen receptor binding
MFIPIGO:0070411I-SMAD binding
MFIEAGO:0070491repressing transcription factor binding
MFIEAGO:0097718disordered domain specific binding

Gene expression in normal tissue: CTNNB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CTNNB1


DatabasePathway IDPathway Des.
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartahespathwaysegmentation clock
biocartapitx2pathwaymulti-step regulation of transcription by pitx2
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartawntpathwaywnt signaling pathway
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-111465Apoptotic cleavage of cellular proteins
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195253Degradation of beta-catenin by the destruction complex
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-196299Beta-catenin phosphorylation cascade
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201722Formation of the beta-catenin:TCF transactivating complex
reactomeR-HSA-201722Formation of the beta-catenin:TCF transactivating complex
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2980736Peptide hormone metabolism
reactomeR-HSA-3134973LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
reactomeR-HSA-351906Apoptotic cleavage of cell adhesion proteins
reactomeR-HSA-375170CDO in myogenesis
reactomeR-HSA-375170CDO in myogenesis
reactomeR-HSA-3769402Deactivation of the beta-catenin transactivating complex
reactomeR-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400508Incretin synthesis, secretion, and inactivation
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-418990Adherens junctions interactions
reactomeR-HSA-421270Cell-cell junction organization
reactomeR-HSA-4411364Binding of TCF/LEF:CTNNB1 to target gene promoters
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-446728Cell junction organization
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4791275Signaling by WNT in cancer
reactomeR-HSA-4839743phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
reactomeR-HSA-5218920VEGFR2 mediated vascular permeability
reactomeR-HSA-525793Myogenesis
reactomeR-HSA-525793Myogenesis
reactomeR-HSA-5339716Misspliced GSK3beta mutants stabilize beta-catenin
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5358747S33 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5358749S37 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5358751S45 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5358752T41 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5626467RHO GTPases activate IQGAPs
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75153Apoptotic execution phase
reactomeR-HSA-8876384Listeria monocytogenes entry into host cells
reactomeR-HSA-8876493InlA-mediated entry of Listeria monocytogenes into host cells
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8951430RUNX3 regulates WNT signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP1591Heart Development
wikipathwaysWP2003miR-targeted genes in leukocytes - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP2118Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathwaysWP2272Pathogenic Escherichia coli infection
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP236Adipogenesis
wikipathwaysWP2363Gastric Cancer Network 2
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP2853Endoderm Differentiation
wikipathwaysWP2858Ectoderm Differentiation
wikipathwaysWP2870Extracellular vesicle-mediated signaling in recipient cells
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP3664Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds
wikipathwaysWP3680Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3969H19 action Rb-E2F1 signaling and CDK-?-catenin activity
wikipathwaysWP3971Role of Osx and miRNAs in tooth development
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4147PTF1A related regulatory pathway
wikipathwaysWP4150Wnt Signaling in Kidney Disease
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP560TGF-beta Receptor Signaling
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
pidap1_pathwayAP-1 transcription factor network
pidar_pathwayCoregulation of Androgen receptor activity
pidarf6_traffickingpathwayArf6 trafficking events
pidbetacatenin_deg_pathwayDegradation of beta catenin
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
pidcdc42_pathwayCDC42 signaling events
pidecadherin_keratinocyte_pathwayE-cadherin signaling in keratinocytes
pidecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
pidecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
pidfoxopathwayFoxO family signaling
pidilk_pathwayIntegrin-linked kinase signaling
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidncadherinpathwayN-cadherin signaling events
pidnectin_pathwayNectin adhesion pathway
pidps1pathwayPresenilin action in Notch and Wnt signaling
pidrac1_pathwayRAC1 signaling pathway
pidtgfbrpathwayTGF-beta receptor signaling
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pidwnt_canonical_pathwayCanonical Wnt signaling pathway
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05100Bacterial invasion of epithelial cells - Homo sapiens (human)
kegghsa05130Pathogenic Escherichia coli infection - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05216Thyroid cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pharmgkbPA152241951Celecoxib Pathway, Pharmacodynamics
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_BCRBCR
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
netpathPathway_GastrinGastrin
netpathPathway_HedgehogHedgehog
netpathPathway_IL5IL5
netpathPathway_TCRTCR
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
netpathPathway_WntWnt

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD103SN-384
iGMDRD28Letrozole8
iGMDRD137Indisulam4
iGMDRD158NSC1415405
iGMDRD105Triptolide4
iGMDRD705Nakiterpiosin3
iGMDRD329Merck602
iGMDRD366PI-1033
iGMDRD286Nsc 6328395
iGMDRD367Ro 28-16751
iGMDRD245FH5352
iGMDRD552AZD-17754
iGMDRD263AACOCF34
iGMDRD719IOX21
iGMDRD564GSK-6503941
iGMDRD405PIK-751
iGMDRD79Gemcitabine3
iGMDRD150RITA3
iGMDRD352PD-03259011
iGMDRD314Tanespimycin8
iGMDRD237ABT-7511
iGMDRD123Isoevodiamine3
iGMDRD260FQI-24
iGMDRD187BRD98763
iGMDRD284Palbociclib1
iGMDRD133Lapatinib1
iGMDRD188Piperlongumine8
iGMDRD399Selumetinib2
iGMDRD74Idarubicin7
iGMDRD64Parbendazole2
iGMDRD190Nilotinib1
iGMDRD420Leucascandrolide A3
iGMDRD151CHM-14
iGMDRD409Saracatinib1
iGMDRD748PHA-6657521
iGMDRD61Kinetin riboside7
iGMDRD470Trametinib1
iGMDRD466Chaetocin4
iGMDRD310Everolimus8
iGMDRD68Paclitaxel1
iGMDRD459RO-33061
iGMDRD231Importazole3
iGMDRD434BMS-5369241
iGMDRD414MST-3123
iGMDRD872BRD71371
iGMDRD42Vorinostat1
iGMDRD886Compound 1541A1
iGMDRD300Tozasertib4
iGMDRD505Pevonedistat4
iGMDRD246NPC264
iGMDRD512nutlin 35
iGMDRD84Lovastatin acid1
iGMDRD456Crizotinib1
iGMDRD125BIRB-7961
iGMDRD116CD4374
iGMDRD424Tamatinib4
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD351GW843682X4
iGMDRD536PLX-47201
iGMDRD211(1S,3R)-RSL33
iGMDRD1014Tankyrase inhibitor2
iGMDRD177Teniposide4
iGMDRD8024-methylfasudil2
iGMDRD255SB2250021
iGMDRD134Sorafenib1
iGMDRD491TAE-6841
iGMDRD440Nutlin-3A4
iGMDRD441TW 376
iGMDRD30917AAG1
iGMDRD782DC-45-A22
iGMDRD562Navitoclax5
iGMDRD100Zebularine1
iGMDRD887Compound 23 citrate3
iGMDRD131Erlotinib2
iGMDRD387CHIR-990211
iGMDRD136Nutlin-31
iGMDRD494Neopeltolide10
iGMDRD142NSC748591
iGMDRD446LY 21832402
iGMDRD71Sparfosic acid3
iGMDRD634SCHEMBL26080416
iGMDRD401Afatinib1
iGMDRD280CYTOCHALASIN B8

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTNNB1

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