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EP300

Summary: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
E1A binding protein p300	MIM:602700	Ensembl:ENSG00000100393	HGNC:HGNC:3373	PA27807	22q13.2

Gene Categories:

TRANSCRIPTION FACTOR BINDING TUMOR SUPPRESSOR DNA REPAIR TRANSCRIPTION FACTOR COMPLEX CLINICALLY ACTIONABLE HISTONE MODIFICATION DRUGGABLE GENOME

GO terms in EP300

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	IPI	GO:0001102	RNA polymerase II activating transcription factor binding
MF	IEA	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MF	IEA	GO:0002039	p53 binding
MF	IDA	GO:0003677	DNA binding
MF	IDA	GO:0003682	chromatin binding
MF	IMP	GO:0003682	chromatin binding
MF	IDA	GO:0003684	damaged DNA binding
MF	IDA	GO:0003713	transcription coactivator activity
MF	TAS	GO:0003713	transcription coactivator activity
MF	IDA	GO:0004402	histone acetyltransferase activity
MF	TAS	GO:0004402	histone acetyltransferase activity
MF	IDA	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0008013	beta-catenin binding
MF	IDA	GO:0008022	protein C-terminus binding
MF	IPI	GO:0008134	transcription factor binding
MF	IEA	GO:0008270	zinc ion binding
MF	EXP	GO:0016407	acetyltransferase activity
MF	IDA	GO:0016407	acetyltransferase activity
MF	IMP	GO:0016407	acetyltransferase activity
MF	IDA	GO:0016746	transferase activity, transferring acyl groups
MF	IEA	GO:0031490	chromatin DNA binding
MF	IPI	GO:0033613	activating transcription factor binding
MF	TAS	GO:0034212	peptide N-acetyltransferase activity
MF	IPI	GO:0035257	nuclear hormone receptor binding
MF	IPI	GO:0050681	androgen receptor binding
MF	TAS	GO:0061733	peptide-lysine-N-acetyltransferase activity
MF	IDA	GO:0061920	protein propionyltransferase activity
MF	IEA	GO:0097157	pre-mRNA intronic binding
MF	IPI	GO:0097677	STAT family protein binding
MF	IDA	GO:0140065	peptide butyryltransferase activity
MF	IDA	GO:0140068	histone crotonyltransferase activity
MF	IEA	GO:0140069	histone butyryltransferase activity
CC	IEA	GO:0000123	histone acetyltransferase complex
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IEA	GO:0005667	transcription factor complex
CC	IEA	GO:0005694	chromosome
CC	IDA	GO:0005829	cytosol
CC	ISS	GO:0032993	protein-DNA complex
BP	IDA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IDA	GO:0001666	response to hypoxia
BP	IEA	GO:0001756	somitogenesis
BP	TAS	GO:0002223	stimulatory C-type lectin receptor signaling pathway
BP	TAS	GO:0006283	transcription-coupled nucleotide-excision repair
BP	IDA	GO:0006355	regulation of transcription, DNA-templated
BP	IEA	GO:0006366	transcription by RNA polymerase II
BP	IDA	GO:0006473	protein acetylation
BP	TAS	GO:0006473	protein acetylation
BP	IDA	GO:0006475	internal protein amino acid acetylation
BP	IMP	GO:0006915	apoptotic process
BP	TAS	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BP	ISS	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
BP	TAS	GO:0007219	Notch signaling pathway
BP	TAS	GO:0007221	positive regulation of transcription of Notch receptor target
BP	TAS	GO:0007399	nervous system development
BP	IEA	GO:0007507	heart development
BP	IEA	GO:0007519	skeletal muscle tissue development
BP	ISS	GO:0007623	circadian rhythm
BP	IEA	GO:0009887	animal organ morphogenesis
BP	TAS	GO:0010506	regulation of autophagy
BP	IDA	GO:0010742	macrophage derived foam cell differentiation
BP	IEA	GO:0016032	viral process
BP	IDA	GO:0016573	histone acetylation
BP	IDA	GO:0018076	N-terminal peptidyl-lysine acetylation
BP	IDA	GO:0018393	internal peptidyl-lysine acetylation
BP	IDA	GO:0018394	peptidyl-lysine acetylation
BP	IEA	GO:0030183	B cell differentiation
BP	IEA	GO:0030220	platelet formation
BP	IEA	GO:0030324	lung development
BP	IMP	GO:0031648	protein destabilization
BP	IEA	GO:0032092	positive regulation of protein binding
BP	IDA	GO:0032460	negative regulation of protein oligomerization
BP	TAS	GO:0032481	positive regulation of type I interferon production
BP	IDA	GO:0034644	cellular response to UV
BP	IEA	GO:0035855	megakaryocyte development
BP	IDA	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BP	IDA	GO:0043627	response to estrogen
BP	IDA	GO:0043923	positive regulation by host of viral transcription
BP	IMP	GO:0043967	histone H4 acetylation
BP	IDA	GO:0043969	histone H2B acetylation
BP	ISS	GO:0045444	fat cell differentiation
BP	TAS	GO:0045652	regulation of megakaryocyte differentiation
BP	TAS	GO:0045747	positive regulation of Notch signaling pathway
BP	IDA	GO:0045815	positive regulation of gene expression, epigenetic
BP	TAS	GO:0045815	positive regulation of gene expression, epigenetic
BP	TAS	GO:0045893	positive regulation of transcription, DNA-templated
BP	IDA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IMP	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	TAS	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	ISS	GO:0050821	protein stabilization
BP	IDA	GO:0051091	positive regulation of DNA-binding transcription factor activity
BP	TAS	GO:0051726	regulation of cell cycle
BP	IDA	GO:0060765	regulation of androgen receptor signaling pathway
BP	TAS	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia
BP	IDA	GO:0061921	peptidyl-lysine propionylation
BP	IDA	GO:0090043	regulation of tubulin deacetylation
BP	IDA	GO:0140066	peptidyl-lysine crotonylation
BP	IDA	GO:0140067	peptidyl-lysine butyrylation
BP	TAS	GO:1900034	regulation of cellular response to heat
BP	TAS	GO:1901796	regulation of signal transduction by p53 class mediator
BP	TAS	GO:1904837	beta-catenin-TCF complex assembly

Gene expression in normal tissue: EP300

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EP300

Database	Pathway ID	Pathway Des.
wikipathways	WP138	Androgen receptor signaling pathway
wikipathways	WP1541	Energy Metabolism
wikipathways	WP179	Cell Cycle
wikipathways	WP1984	Integrated Breast Cancer Pathway
wikipathways	WP2261	Signaling Pathways in Glioblastoma
wikipathways	WP2586	Aryl Hydrocarbon Receptor
wikipathways	WP2873	Aryl Hydrocarbon Receptor Pathway
wikipathways	WP2882	Nuclear Receptors Meta-Pathway
wikipathways	WP304	Kit receptor signaling pathway
wikipathways	WP3414	Initiation of transcription and translation elongation at the HIV-1 LTR
wikipathways	WP3651	Pathways Affected in Adenoid Cystic Carcinoma
wikipathways	WP3657	Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex
wikipathways	WP366	TGF-beta Signaling Pathway
wikipathways	WP395	IL-4 Signaling Pathway
wikipathways	WP399	Wnt Signaling Pathway and Pluripotency
wikipathways	WP3995	Prion disease pathway
wikipathways	WP4018	Pathways in clear cell renal cell carcinoma
wikipathways	WP4180	Ebola Virus Pathway on Host
wikipathways	WP4217	Ebola Virus Pathway on Host
wikipathways	WP4241	Type 2 papillary renal cell carcinoma
wikipathways	WP560	TGF-beta Receptor Signaling
wikipathways	WP61	Notch Signaling Pathway
wikipathways	WP706	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
netpath	Pathway_AndrogenReceptor	AndrogenReceptor
netpath	Pathway_IL4	IL4
netpath	Pathway_IL6	IL6
netpath	Pathway_KitReceptor	KitReceptor
netpath	Pathway_Notch	Notch
netpath	Pathway_Oncostatin_M	Oncostatin_M
netpath	Pathway_TGF_beta_Receptor	TGF_beta_Receptor
netpath	Pathway_TNFalpha	TNFalpha
pid	ap1_pathway	AP-1 transcription factor network
pid	ar_tf_pathway	Regulation of Androgen receptor activity
pid	atf2_pathway	ATF-2 transcription factor network
pid	betacatenin_nuc_pathway	Regulation of nuclear beta catenin signaling and target gene transcription
pid	cmyb_pathway	C-MYB transcription factor network
pid	e2f_pathway	E2F transcription factor network
pid	era_genomic_pathway	Validated nuclear estrogen receptor alpha network
pid	foxm1pathway	FOXM1 transcription factor network
pid	foxopathway	FoxO family signaling
pid	fra_pathway	Validated transcriptional targets of AP1 family members Fra1 and Fra2
pid	hdac_classi_pathway	Signaling events mediated by HDAC Class I
pid	hdac_classiii_pathway	Signaling events mediated by HDAC Class III
pid	hes_heypathway	Notch-mediated HES/HEY network
pid	hif1_tfpathway	HIF-1-alpha transcription factor network
pid	hif2pathway	HIF-2-alpha transcription factor network
pid	hnf3apathway	FOXA1 transcription factor network
pid	ifngpathway	IFN-gamma pathway
pid	myc_activpathway	Validated targets of C-MYC transcriptional activation
pid	myc_represspathway	Validated targets of C-MYC transcriptional repression
pid	nfat_3pathway	Role of Calcineurin-dependent NFAT signaling in lymphocytes
pid	notch_pathway	Notch signaling pathway
pid	p53downstreampathway	Direct p53 effectors
pid	p53regulationpathway	p53 pathway
pid	p73pathway	p73 transcription factor network
pid	rb_1pathway	Regulation of retinoblastoma protein
pid	reg_gr_pathway	Glucocorticoid receptor regulatory network
pid	retinoic_acid_pathway	Retinoic acid receptors-mediated signaling
pid	smad2_3nuclearpathway	Regulation of nuclear SMAD2/3 signaling
pid	tap63pathway	Validated transcriptional targets of TAp63 isoforms
kegg	hsa04024	cAMP signaling pathway - Homo sapiens (human)
kegg	hsa04066	HIF-1 signaling pathway - Homo sapiens (human)
kegg	hsa04068	FoxO signaling pathway - Homo sapiens (human)
kegg	hsa04110	Cell cycle - Homo sapiens (human)
kegg	hsa04310	Wnt signaling pathway - Homo sapiens (human)
kegg	hsa04330	Notch signaling pathway - Homo sapiens (human)
kegg	hsa04350	TGF-beta signaling pathway - Homo sapiens (human)
kegg	hsa04520	Adherens junction - Homo sapiens (human)
kegg	hsa04630	Jak-STAT signaling pathway - Homo sapiens (human)
kegg	hsa04720	Long-term potentiation - Homo sapiens (human)
kegg	hsa04916	Melanogenesis - Homo sapiens (human)
kegg	hsa04919	Thyroid hormone signaling pathway - Homo sapiens (human)
kegg	hsa04922	Glucagon signaling pathway - Homo sapiens (human)
kegg	hsa05016	Huntington,s disease - Homo sapiens (human)
kegg	hsa05152	Tuberculosis - Homo sapiens (human)
kegg	hsa05161	Hepatitis B - Homo sapiens (human)
kegg	hsa05164	Influenza A - Homo sapiens (human)
kegg	hsa05165	Human papillomavirus infection - Homo sapiens (human)
kegg	hsa05166	HTLV-I infection - Homo sapiens (human)
kegg	hsa05167	Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegg	hsa05168	Herpes simplex infection - Homo sapiens (human)
kegg	hsa05169	Epstein-Barr virus infection - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05203	Viral carcinogenesis - Homo sapiens (human)
kegg	hsa05206	MicroRNAs in cancer - Homo sapiens (human)
kegg	hsa05211	Renal cell carcinoma - Homo sapiens (human)
kegg	hsa05215	Prostate cancer - Homo sapiens (human)
biocarta	carm1pathway	transcription regulation by methyltransferase of carm1
biocarta	carmerpathway	carm1 and regulation of the estrogen receptor
biocarta	eponfkbpathway	erythropoietin mediated neuroprotection through nf-kb
biocarta	g2pathway	cell cycle: g2/m checkpoint
biocarta	her2pathway	role of erbb2 in signal transduction and oncology
biocarta	hifpathway	hypoxia-inducible factor in the cardivascular system
biocarta	il7pathway	il-7 signal transduction
biocarta	mef2dpathway	role of mef2d in t-cell apoptosis
biocarta	melanocytepathway	melanocyte development and pigmentation pathway
biocarta	nthipathway	nfkb activation by nontypeable hemophilus influenzae
biocarta	p53hypoxiapathway	hypoxia and p53 in the cardiovascular system
biocarta	pelp1pathway	pelp1 modulation of estrogen receptor activity
biocarta	pitx2pathway	multi-step regulation of transcription by pitx2
biocarta	pparapathway	mechanism of gene regulation by peroxisome proliferators via ppara
biocarta	relapathway	acetylation and deacetylation of rela in nucleus
biocarta	tgfbpathway	tgf beta signaling pathway
reactome	R-HSA-1234158	Regulation of gene expression by Hypoxia-inducible Factor
reactome	R-HSA-1234174	Regulation of Hypoxia-inducible Factor (HIF) by oxygen
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1368082	RORA activates gene expression
reactome	R-HSA-1368082	RORA activates gene expression
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-156711	Polo-like kinase mediated events
reactome	R-HSA-157118	Signaling by NOTCH
reactome	R-HSA-157118	Signaling by NOTCH
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-1643685	Disease
reactome	R-HSA-168249	Innate Immune System
reactome	R-HSA-168256	Immune System
reactome	R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactome	R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA
reactome	R-HSA-186712	Regulation of beta-cell development
reactome	R-HSA-1912408	Pre-NOTCH Transcription and Translation
reactome	R-HSA-1912408	Pre-NOTCH Transcription and Translation
reactome	R-HSA-1912422	Pre-NOTCH Expression and Processing
reactome	R-HSA-1912422	Pre-NOTCH Expression and Processing
reactome	R-HSA-195721	Signaling by WNT
reactome	R-HSA-1980143	Signaling by NOTCH1
reactome	R-HSA-1980143	Signaling by NOTCH1
reactome	R-HSA-1980145	Signaling by NOTCH2
reactome	R-HSA-1989781	PPARA activates gene expression
reactome	R-HSA-201681	TCF dependent signaling in response to WNT
reactome	R-HSA-201722	Formation of the beta-catenin:TCF transactivating complex
reactome	R-HSA-210744	Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
reactome	R-HSA-212165	Epigenetic regulation of gene expression
reactome	R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription
reactome	R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-2197563	NOTCH2 intracellular domain regulates transcription
reactome	R-HSA-2262749	Cellular response to hypoxia
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-2644602	Signaling by NOTCH1 PEST Domain Mutants in Cancer
reactome	R-HSA-2644603	Signaling by NOTCH1 in Cancer
reactome	R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants
reactome	R-HSA-2894858	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
reactome	R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
reactome	R-HSA-2990846	SUMOylation
reactome	R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins
reactome	R-HSA-3134973	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
reactome	R-HSA-3214847	HATs acetylate histones
reactome	R-HSA-3247509	Chromatin modifying enzymes
reactome	R-HSA-3371556	Cellular response to heat stress
reactome	R-HSA-3371568	Attenuation phase
reactome	R-HSA-3371571	HSF1-dependent transactivation
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-381340	Transcriptional regulation of white adipocyte differentiation
reactome	R-HSA-381340	Transcriptional regulation of white adipocyte differentiation
reactome	R-HSA-3899300	SUMOylation of transcription cofactors
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactome	R-HSA-400253	Circadian Clock
reactome	R-HSA-400253	Circadian Clock
reactome	R-HSA-453274	Mitotic G2-G2/M phases
reactome	R-HSA-4839726	Chromatin organization
reactome	R-HSA-5250913	Positive epigenetic regulation of rRNA expression
reactome	R-HSA-5250924	B-WICH complex positively regulates rRNA expression
reactome	R-HSA-556833	Metabolism of lipids
reactome	R-HSA-5617472	Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactome	R-HSA-5619507	Activation of HOX genes during differentiation
reactome	R-HSA-5621481	C-type lectin receptors (CLRs)
reactome	R-HSA-5621575	CD209 (DC-SIGN) signaling
reactome	R-HSA-5633007	Regulation of TP53 Activity
reactome	R-HSA-5663202	Diseases of signal transduction
reactome	R-HSA-5688426	Deubiquitination
reactome	R-HSA-5689901	Metalloprotease DUBs
reactome	R-HSA-5696398	Nucleotide Excision Repair
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-6781823	Formation of TC-NER Pre-Incision Complex
reactome	R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
reactome	R-HSA-6782135	Dual incision in TC-NER
reactome	R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER
reactome	R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes
reactome	R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
reactome	R-HSA-6804758	Regulation of TP53 Activity through Acetylation
reactome	R-HSA-6804760	Regulation of TP53 Activity through Methylation
reactome	R-HSA-6811555	PI5P Regulates TP53 Acetylation
reactome	R-HSA-69275	G2/M Transition
reactome	R-HSA-69278	Cell Cycle, Mitotic
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-73894	DNA Repair
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-8864260	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
reactome	R-HSA-8866907	Activation of the TFAP2 (AP-2) family of transcription factors
reactome	R-HSA-8878159	Transcriptional regulation by RUNX3
reactome	R-HSA-8878159	Transcriptional regulation by RUNX3
reactome	R-HSA-8878171	Transcriptional regulation by RUNX1
reactome	R-HSA-8936459	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
reactome	R-HSA-8939211	ESR-mediated signaling
reactome	R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
reactome	R-HSA-8941856	RUNX3 regulates NOTCH signaling
reactome	R-HSA-8941856	RUNX3 regulates NOTCH signaling
reactome	R-HSA-8941858	Regulation of RUNX3 expression and activity
reactome	R-HSA-8951936	RUNX3 regulates p14-ARF
reactome	R-HSA-8953897	Cellular responses to external stimuli
reactome	R-HSA-9006931	Signaling by Nuclear Receptors
reactome	R-HSA-9012852	Signaling by NOTCH3
reactome	R-HSA-9012852	Signaling by NOTCH3
reactome	R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription
reactome	R-HSA-9013508	NOTCH3 Intracellular Domain Regulates Transcription
reactome	R-HSA-9013694	Signaling by NOTCH4
reactome	R-HSA-9013695	NOTCH4 Intracellular Domain Regulates Transcription
reactome	R-HSA-9018519	Estrogen-dependent gene expression
reactome	R-HSA-918233	TRAF3-dependent IRF activation pathway
reactome	R-HSA-933541	TRAF6 mediated IRF7 activation

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD171	Pemetrexed	2
iGMDRD52	Rotenone	1
iGMDRD593	CX-5461	1
iGMDRD260	FQI-2	4
iGMDRD507	GSK690693	1
iGMDRD493	GSK269962A	2
iGMDRD64	Parbendazole	3
iGMDRD656	XMD 8-92	1
iGMDRD23	Gossypol	4
iGMDRD356	PNU-74654	2
iGMDRD188	Piperlongumine	4
iGMDRD399	Selumetinib	4
iGMDRD74	Idarubicin	5
iGMDRD506	Fedratinib	6
iGMDRD146	Elesclomol	1
iGMDRD670	ML 210	4
iGMDRD283	Bosutinib	1
iGMDRD781	Sirolimus	2
iGMDRD126	Tipifarnib	3
iGMDRD151	CHM-1	4
iGMDRD420	Leucascandrolide A	7
iGMDRD466	Chaetocin	3
iGMDRD1032	VNLG/124	1
iGMDRD687	I-BET151	1
iGMDRD61	Kinetin riboside	6
iGMDRD105	Triptolide	3
iGMDRD221	Tamoxifen	1
iGMDRD289	Parthenolide	2
iGMDRD705	Nakiterpiosin	3
iGMDRD77	Itraconazole	3
iGMDRD103	SN-38	6
iGMDRD672	Alectinib	1
iGMDRD137	Indisulam	2
iGMDRD293	Bleomycin	1
iGMDRD158	NSC141540	3
iGMDRD402	AKT Inhibitor VIII	1
iGMDRD552	AZD-1775	4
iGMDRD263	AACOCF3	4
iGMDRD119	Temsirolimus	1
iGMDRD286	Nsc 632839	5
iGMDRD662	JQ-1	1
iGMDRD329	Merck60	3
iGMDRD366	PI-103	4
iGMDRD560	MK-2206	5
iGMDRD532	Olaparib	1
iGMDRD150	RITA	3
iGMDRD405	PIK-75	2
iGMDRD475	BX 912	1
iGMDRD324	CI-1040	1
iGMDRD123	Isoevodiamine	2
iGMDRD605	AZD6482	2
iGMDRD461	VX-11e	2
iGMDRD314	Tanespimycin	2
iGMDRD758	JW-7-24-1	1
iGMDRD441	TW 37	5
iGMDRD255	SB225002	8
iGMDRD364	CP-724714	1
iGMDRD454	JNK Inhibitor VIII	1
iGMDRD887	Compound 23 citrate	2
iGMDRD332	A-770041	1
iGMDRD562	Navitoclax	4
iGMDRD144	NSC95397	2
iGMDRD462	OSI-906 (Linsitinib)	1
iGMDRD494	Neopeltolide	5
iGMDRD599	Salermide	3
iGMDRD772	BRD4770	3
iGMDRD297	Austocystin D	1
iGMDRD348	BMS-345541	1
iGMDRD280	CYTOCHALASIN B	1
iGMDRD378	ZM-447439	1
iGMDRD776	QL-XI-92	1
iGMDRD446	LY 2183240	6
iGMDRD608	Refametinib	2
iGMDRD71	Sparfosic acid	3
iGMDRD193	Fqi1	2
iGMDRD459	RO-3306	1
iGMDRD504	Obatoclax	1
iGMDRD267	Oligomycin A	3
iGMDRD231	Importazole	1
iGMDRD300	Tozasertib	1
iGMDRD191	FMK	2
iGMDRD886	Compound 1541A	1
iGMDRD505	Pevonedistat	2
iGMDRD246	NPC26	7
iGMDRD695	FR-180204	1
iGMDRD646	PHA-793887	1
iGMDRD872	BRD7137	5
iGMDRD116	CD437	7
iGMDRD614	Dabrafenib	1
iGMDRD160	Cis-Platin	1
iGMDRD262	KU-55933	1
iGMDRD347	Y-39983	3
iGMDRD512	nutlin 3	3
iGMDRD148	Pifithrin-mu	2
iGMDRD211	(1S,3R)-RSL3	3
iGMDRD132	(-)-gallocatechin-3-O-gallate	5
iGMDRD85	Ursolic acid	1
iGMDRD689	EX-8678	1
iGMDRD351	GW843682X	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EP300

SITE

DATATYPES

CLASSFICATION

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