ERBB3
Summary: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| erb-b2 receptor tyrosine kinase 3 | MIM:190151 | Ensembl:ENSG00000065361 | HGNC:HGNC:3431 | PA27846 | 12q13.2 |
GO terms in ERBB3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005622 | intracellular |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0009925 | basal plasma membrane |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0016328 | lateral plasma membrane |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
| CC | ISS | GO:0043235 | receptor complex |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0003197 | endocardial cushion development |
| BP | IDA | GO:0007162 | negative regulation of cell adhesion |
| BP | IDA | GO:0007165 | signal transduction |
| BP | ISS | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ISS | GO:0007422 | peripheral nervous system development |
| BP | ISS | GO:0007507 | heart development |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IDA | GO:0009968 | negative regulation of signal transduction |
| BP | IEA | GO:0010628 | positive regulation of gene expression |
| BP | ISS | GO:0014037 | Schwann cell differentiation |
| BP | IDA | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | TAS | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0021545 | cranial nerve development |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | NAS | GO:0042060 | wound healing |
| BP | IDA | GO:0042127 | regulation of cell proliferation |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | ISS | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IDA | GO:0051048 | negative regulation of secretion |
| BP | IMP | GO:0051402 | neuron apoptotic process |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0055025 | positive regulation of cardiac muscle tissue development |
| BP | IMP | GO:0061098 | positive regulation of protein tyrosine kinase activity |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade |
| BP | IMP | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | TAS | GO:2000145 | regulation of cell motility |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | ISS | GO:0004888 | transmembrane signaling receptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019838 | growth factor binding |
| MF | ISS | GO:0019838 | growth factor binding |
| MF | IDA | GO:0030296 | protein tyrosine kinase activator activity |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IBA | GO:0038131 | neuregulin receptor activity |
| MF | IBA | GO:0038132 | neuregulin binding |
| MF | IDA | GO:0038132 | neuregulin binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | NAS | GO:0042803 | protein homodimerization activity |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: ERBB3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ERBB3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | erbb_network_pathway | ErbB receptor signaling network |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_TNFalpha | TNFalpha |
| wikipathways | WP1591 | Heart Development |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP673 | ErbB Signaling Pathway |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1306955 | GRB7 events in ERBB2 signaling |
| reactome | R-HSA-1358803 | Downregulation of ERBB2:ERBB3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1963642 | PI3K events in ERBB2 signaling |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6785631 | ERBB2 Regulates Cell Motility |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-8847993 | ERBB2 Activates PTK6 Signaling |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8863795 | Downregulation of ERBB2 signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | erbb3pathway | neuroregulin receptor degredation protein-1 controls erbb3 receptor recycling |
| biocarta | her2pathway | role of erbb2 in signal transduction and oncology |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD882 | CIL41 | 1 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD545 | SGX-523 | 1 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD479 | Veliparib | 1 |
| iGMDRD157 | Ouabain | 1 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD333 | MEK Inhibitor | 6 |
| iGMDRD35 | PD153035 | 1 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD192 | CIL56 | 1 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD95 | Isonicotinohydroxamic acid | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 5 |
| iGMDRD435 | BI-2536 | 1 |
| iGMDRD750 | TRIAZOLOTHIADIAZINE | 1 |
| iGMDRD426 | WP1130 | 1 |
| iGMDRD346 | Nintedanib | 1 |
| iGMDRD633 | AVICIN D | 1 |
| iGMDRD898 | EGFR mAb inhibitor | 1 |
| iGMDRD1020 | Trastuzumab | 3 |
| iGMDRD792 | Cetuximab | 1 |
| iGMDRD798 | Ceranib-2 | 1 |
| iGMDRD382 | CEP-701 | 1 |
| iGMDRD262 | KU-55933 | 1 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD185 | DMOG | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD444 | Tivantinib | 1 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD364 | CP-724714 | 1 |
| iGMDRD96 | S-Trityl-L-cysteine | 1 |
| iGMDRD33 | Entinostat | 1 |
| iGMDRD109 | Gefitinib | 1 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD613 | CHEMBL258148 | 1 |
| iGMDRD574 | Ruxolitinib | 1 |
| iGMDRD1037 | X1S.3R.RSL.3 | 1 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD203 | STF-31 | 1 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD253 | Vincaleukoblastine | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD189 | CGP 60474 | 1 |
| iGMDRD380 | Pifithrin-alpha | 1 |
| iGMDRD829 | AV-203 | 1 |
| iGMDRD710 | BRD-K96970199 | 1 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD401 | Afatinib | 17 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD979 | Pertuzumab | 4 |
| iGMDRD313 | Axitinib | 1 |
| iGMDRD199 | RG108 | 2 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD119 | Temsirolimus | 1 |
| iGMDRD658 | CHEMBL1673039 | 1 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD421 | AZD7762 | 1 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD803 | 9F7-F11 | 1 |
| iGMDRD787 | PF 184 | 1 |
| iGMDRD439 | KW-2449 | 1 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD251 | ML162 | 1 |
| iGMDRD197 | DBeQ | 1 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD170 | Fluvastatin | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD540 | Alisertib | 1 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD841 | BRD-A05715709 | 1 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD569 | MOMELOTINIB | 1 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD594 | AZD-8055 | 1 |
| iGMDRD423 | AT 7867 | 1 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD146 | Elesclomol | 1 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD349 | Lenvatinib | 1 |
| iGMDRD133 | Lapatinib | 4 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD431 | NU-7441 | 2 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD458 | GSK-319347A | 1 |
| iGMDRD493 | GSK269962A | 1 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD474 | Avrainvillamide | 6 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD816 | anti-EGFR mAbs | 1 |
| iGMDRD983 | PI3K pathway inhibitor | 6 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD905 | ERBB3 mAb inhibitor | 2 |
| iGMDRD358 | Semagacestat | 1 |
| iGMDRD819 | anti-HER3 mAbs | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD675 | Kinome_3629 | 1 |
| iGMDRD425 | ERASTIN | 1 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD76 | Simvastatin | 1 |
| iGMDRD75 | Lovastatin | 1 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD670 | ML 210 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ERBB3
CLASSFICATION
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