PDGFRB
Summary: The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| platelet derived growth factor receptor beta | MIM:173410 | Ensembl:ENSG00000113721 | HGNC:HGNC:8804 | PA33148 | 5q32 |
GO terms in PDGFRB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | TAS | GO:0004992 | platelet activating factor receptor activity |
| MF | IBA | GO:0005017 | platelet-derived growth factor-activated receptor activity |
| MF | TAS | GO:0005017 | platelet-derived growth factor-activated receptor activity |
| MF | IBA | GO:0005019 | platelet-derived growth factor beta-receptor activity |
| MF | IDA | GO:0005019 | platelet-derived growth factor beta-receptor activity |
| MF | IMP | GO:0005019 | platelet-derived growth factor beta-receptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0019838 | growth factor binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0038085 | vascular endothelial growth factor binding |
| MF | IEA | GO:0043548 | phosphatidylinositol 3-kinase binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IBA | GO:0048407 | platelet-derived growth factor binding |
| MF | IDA | GO:0048407 | platelet-derived growth factor binding |
| MF | IPI | GO:0048407 | platelet-derived growth factor binding |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0006024 | glycosaminoglycan biosynthetic process |
| BP | IDA | GO:0007165 | signal transduction |
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007568 | aging |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008584 | male gonad development |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IDA | GO:0010863 | positive regulation of phospholipase C activity |
| BP | ISS | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IMP | GO:0014911 | positive regulation of smooth muscle cell migration |
| BP | ISS | GO:0014911 | positive regulation of smooth muscle cell migration |
| BP | IMP | GO:0016477 | cell migration |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IDA | GO:0032516 | positive regulation of phosphoprotein phosphatase activity |
| BP | IEA | GO:0032526 | response to retinoic acid |
| BP | ISS | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IEA | GO:0032967 | positive regulation of collagen biosynthetic process |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IEA | GO:0034405 | response to fluid shear stress |
| BP | IEA | GO:0035025 | positive regulation of Rho protein signal transduction |
| BP | ISS | GO:0035441 | cell migration involved in vasculogenesis |
| BP | IEA | GO:0035789 | metanephric mesenchymal cell migration |
| BP | IMP | GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway |
| BP | ISS | GO:0035793 | positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway |
| BP | ISS | GO:0035909 | aorta morphogenesis |
| BP | IEA | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| BP | IBA | GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway |
| BP | IDA | GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway |
| BP | IEA | GO:0042060 | wound healing |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IDA | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| BP | IEA | GO:0043627 | response to estrogen |
| BP | ISS | GO:0045840 | positive regulation of mitotic nuclear division |
| BP | IMP | GO:0046488 | phosphatidylinositol metabolic process |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IDA | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | IMP | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | IEA | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | IMP | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | ISS | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0048839 | inner ear development |
| BP | ISS | GO:0050921 | positive regulation of chemotaxis |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | ISS | GO:0055003 | cardiac myofibril assembly |
| BP | IEA | GO:0055093 | response to hyperoxia |
| BP | IDA | GO:0060326 | cell chemotaxis |
| BP | IEA | GO:0060437 | lung growth |
| BP | ISS | GO:0060981 | cell migration involved in coronary angiogenesis |
| BP | ISS | GO:0061298 | retina vasculature development in camera-type eye |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:0071670 | smooth muscle cell chemotaxis |
| BP | IEA | GO:0072075 | metanephric mesenchyme development |
| BP | ISS | GO:0072262 | metanephric glomerular mesangial cell proliferation involved in metanephros development |
| BP | ISS | GO:0072277 | metanephric glomerular capillary formation |
| BP | IEA | GO:0072278 | metanephric comma-shaped body morphogenesis |
| BP | IEA | GO:0072284 | metanephric S-shaped body morphogenesis |
| BP | ISS | GO:0090280 | positive regulation of calcium ion import |
| BP | ISS | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| BP | IEA | GO:2000491 | positive regulation of hepatic stellate cell activation |
| BP | ISS | GO:2000573 | positive regulation of DNA biosynthetic process |
| CC | ISS | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0009986 | cell surface |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | ISS | GO:0016324 | apical plasma membrane |
| CC | IDA | GO:0031226 | intrinsic component of plasma membrane |
| CC | IEA | GO:0031410 | cytoplasmic vesicle |
| CC | IEA | GO:0043202 | lysosomal lumen |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IBA | GO:0043235 | receptor complex |
Gene expression in normal tissue: PDGFRB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDGFRB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2526 | PDGF Pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP322 | Osteoblast Signaling |
| wikipathways | WP3640 | Imatinib and Chronic Myeloid Leukemia |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP3981 | miRNA regulation of prostate cancer signaling pathways |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| pid | integrin3_pathway | Beta3 integrin cell surface interactions |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | nectin_pathway | Nectin adhesion pathway |
| pid | pdgf_pathway | PDGF receptor signaling network |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | s1p_s1p1_pathway | S1P1 pathway |
| pid | s1p_s1p3_pathway | S1P3 pathway |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| pharmgkb | PA165959425 | Pathway_PA165959425 |
| pharmgkb | PA165959584 | Sorafenib Pharmacodynamics |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD602 | Foretinib | 1 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD340 | SU 11274 | 1 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD349 | Lenvatinib | 1 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD994 | QW-BI-011 | 1 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD474 | Avrainvillamide | 6 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD259 | EX-527 | 1 |
| iGMDRD760 | ML239 | 1 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD484 | Pluripotin | 1 |
| iGMDRD75 | Lovastatin | 1 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD420 | Leucascandrolide A | 6 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD249 | CCT036477 | 1 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD526 | KX2-391 | 1 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD119 | Temsirolimus | 1 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD327 | LBH-589 | 1 |
| iGMDRD197 | DBeQ | 1 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD244 | ML311 | 1 |
| iGMDRD186 | SMER3 | 1 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD221 | Tamoxifen | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD439 | KW-2449 | 1 |
| iGMDRD787 | PF 184 | 1 |
| iGMDRD228 | ML029 | 1 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD251 | ML162 | 1 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD841 | BRD-A05715709 | 1 |
| iGMDRD170 | Fluvastatin | 1 |
| iGMDRD540 | Alisertib | 1 |
| iGMDRD548 | Marinopyrrole A | 1 |
| iGMDRD108 | CI-976 | 1 |
| iGMDRD242 | ML050 | 1 |
| iGMDRD50 | Cytarabine | 1 |
| iGMDRD423 | AT 7867 | 1 |
| iGMDRD150 | RITA | 1 |
| iGMDRD681 | SB-743921 | 1 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD304 | CH 55 | 1 |
| iGMDRD444 | Tivantinib | 2 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD533 | HSCI1_000270 | 1 |
| iGMDRD842 | BRD-A71883111 | 1 |
| iGMDRD577 | BIX01294 | 8 |
| iGMDRD609 | BRD-K66453893 | 1 |
| iGMDRD55 | Pyrazolanthrone | 1 |
| iGMDRD637 | BRD-K37390332 | 1 |
| iGMDRD574 | Ruxolitinib | 1 |
| iGMDRD1037 | X1S.3R.RSL.3 | 1 |
| iGMDRD261 | OSI-027 | 1 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD846 | BRD-K24690302 | 1 |
| iGMDRD134 | Sorafenib | 1 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD613 | CHEMBL258148 | 1 |
| iGMDRD422 | Regorafenib | 1 |
| iGMDRD320 | PIK-93 | 1 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD697 | Methylstat | 1 |
| iGMDRD359 | OSW-1 | 3 |
| iGMDRD66 | Doxorubicin | 1 |
| iGMDRD528 | rigosertib | 1 |
| iGMDRD797 | ISOX DUAL | 1 |
| iGMDRD258 | SB-431542 | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD313 | Axitinib | 1 |
| iGMDRD685 | AZD4547 | 1 |
| iGMDRD502 | AZD1480 | 1 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD246 | NPC26 | 5 |
| iGMDRD882 | CIL41 | 1 |
| iGMDRD872 | BRD7137 | 9 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD415 | LE-135 | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD435 | BI-2536 | 1 |
| iGMDRD426 | WP1130 | 1 |
| iGMDRD750 | TRIAZOLOTHIADIAZINE | 1 |
| iGMDRD492 | HBX-41108 | 1 |
| iGMDRD346 | Nintedanib | 1 |
| iGMDRD765 | BRD-K51490254 | 1 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD410 | Ko-143 | 3 |
| iGMDRD798 | Ceranib-2 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDGFRB
CLASSFICATION
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