STK11


Summary: This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
serine/threonine kinase 11MIM:602216Ensembl:ENSG00000118046HGNC:HGNC:11389PA3619819p13.3

GO terms in STK11


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCIDAGO:0005829cytosol
CCISSGO:0005829cytosol
CCTASGO:0005829cytosol
CCISSGO:0016020membrane
CCIEAGO:0036398TCR signalosome
CCHDAGO:0070062extracellular exosome
BPISSGO:0001558regulation of cell growth
BPIEAGO:0001894tissue homeostasis
BPISSGO:0001944vasculature development
BPIDAGO:0006468protein phosphorylation
BPIEAGO:0006914autophagy
BPIMPGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0007050cell cycle arrest
BPTASGO:0007050cell cycle arrest
BPIEAGO:0007283spermatogenesis
BPIEAGO:0007409axonogenesis
BPIMPGO:0008285negative regulation of cell proliferation
BPISSGO:0010212response to ionizing radiation
BPIMPGO:0010508positive regulation of autophagy
BPISSGO:0030010establishment of cell polarity
BPIEAGO:0030111regulation of Wnt signaling pathway
BPISSGO:0030308negative regulation of cell growth
BPIMPGO:0030511positive regulation of transforming growth factor beta receptor signaling pathway
BPIEAGO:0032147activation of protein kinase activity
BPIEAGO:0036399TCR signalosome assembly
BPISSGO:0042593glucose homeostasis
BPIMPGO:0043276anoikis
BPIEAGO:0045059positive thymic T cell selection
BPIDAGO:0046777protein autophosphorylation
BPIEAGO:0048814regulation of dendrite morphogenesis
BPIEAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIEAGO:0050772positive regulation of axonogenesis
BPIEAGO:0050852T cell receptor signaling pathway
BPIEAGO:0051055negative regulation of lipid biosynthetic process
BPIEAGO:0051645Golgi localization
BPIEAGO:0051896regulation of protein kinase B signaling
BPIEAGO:0060070canonical Wnt signaling pathway
BPIEAGO:0060770negative regulation of epithelial cell proliferation involved in prostate gland development
BPIDAGO:0071493cellular response to UV-B
BPIDAGO:0072332intrinsic apoptotic signaling pathway by p53 class mediator
BPIEAGO:0097484dendrite extension
BPIEAGO:1900182positive regulation of protein localization to nucleus
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPIMPGO:1904262negative regulation of TORC1 signaling
MFIDAGO:0000287magnesium ion binding
MFIDAGO:0002039p53 binding
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIEAGO:0030275LRR domain binding
MFIDAGO:0030295protein kinase activator activity

Gene expression in normal tissue: STK11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STK11


DatabasePathway IDPathway Des.
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2571Polycystic Kidney Disease Pathway
wikipathwaysWP3595mir-124 predicted interactions with cell cycle and differentiation
wikipathwaysWP3878ATM Signaling Network in Development and Disease
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
netpathPathway_EGFR1EGFR1
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
pidlkb1_pathwayLKB1 signaling events
pharmgkbPA165948566Metformin Pathway, Pharmacodynamic
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-163680AMPK inhibits chREBP transcriptional activation activity
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-165159mTOR signalling
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-380972Energy dependent regulation of mTOR by LKB1-AMPK
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD64Parbendazole2
iGMDRD190Nilotinib1
iGMDRD524ISX-93
iGMDRD874BRD89581
iGMDRD356PNU-746541
iGMDRD399Selumetinib2
iGMDRD133Lapatinib1
iGMDRD188Piperlongumine6
iGMDRD780PP-304
iGMDRD888Compound 446
iGMDRD117Docetaxel4
iGMDRD284Palbociclib1
iGMDRD207Capsaicin1
iGMDRD294Batimastat3
iGMDRD52Rotenone6
iGMDRD474Avrainvillamide4
iGMDRD778SCHEMBL135867083
iGMDRD466Chaetocin4
iGMDRD679Bistramide A1
iGMDRD290SB-2021901
iGMDRD61Kinetin riboside1
iGMDRD748PHA-6657521
iGMDRD152179324-69-712
iGMDRD427ABT7372
iGMDRD546BMS-7548071
iGMDRD781Sirolimus2
iGMDRD151CHM-11
iGMDRD409Saracatinib1
iGMDRD126Tipifarnib2
iGMDRD425ERASTIN1
iGMDRD147Prima-12
iGMDRD263AACOCF34
iGMDRD322FK 8664
iGMDRD264Bryostatin 11
iGMDRD367Ro 28-16751
iGMDRD662JQ-13
iGMDRD289Parthenolide8
iGMDRD105Triptolide6
iGMDRD372TGX 2211
iGMDRD251ML1629
iGMDRD202Curcumin5
iGMDRD121GMX17785
iGMDRD949mTOR inhibitor4
iGMDRD402AKT Inhibitor VIII1
iGMDRD467Motesanib1
iGMDRD883CIL55A2
iGMDRD511CHEMBL3993791
iGMDRD945ML21412
iGMDRD154NSC237664
iGMDRD1002rTRAIL1
iGMDRD219Bax channel blocker4
iGMDRD698Neratinib9
iGMDRD352PD-03259011
iGMDRD79Gemcitabine2
iGMDRD1010SRC inhibitor (in combination with PI3K/MEK inhibitors)1
iGMDRD131Erlotinib2
iGMDRD690PRIMA-1MET1
iGMDRD835BET inhibitor2
iGMDRD268Cerulenin5
iGMDRD332A-7700411
iGMDRD287Myricetin1
iGMDRD887Compound 23 citrate1
iGMDRD562Navitoclax1
iGMDRD398Sepantronium1
iGMDRD577BIX012945
iGMDRD782DC-45-A24
iGMDRD30917AAG3
iGMDRD870BRD636101
iGMDRD441TW 371
iGMDRD318PAC-18
iGMDRD138PX 127
iGMDRD491TAE-6841
iGMDRD270Ciclosporin1
iGMDRD33Entinostat1
iGMDRD134Sorafenib1
iGMDRD348BMS-3455411
iGMDRD776QL-XI-921
iGMDRD218XAV 9391
iGMDRD1009SRC inhibitor2
iGMDRD498GW441756X2
iGMDRD446LY 21832402
iGMDRD608Refametinib1
iGMDRD193Fqi11
iGMDRD163all trans Retinoic Acid1
iGMDRD144NSC953975
iGMDRD239Dasatinib1
iGMDRD136Nutlin-31
iGMDRD659Avagacestat (BMS-708163)1
iGMDRD772BRD47704
iGMDRD54Phenformin3
iGMDRD886Compound 1541A1
iGMDRD42Vorinostat1
iGMDRD882CIL413
iGMDRD414MST-3124
iGMDRD985PI3K/MEK inhibitor2
iGMDRD68Paclitaxel1
iGMDRD333MEK Inhibitor6
iGMDRD271Brefeldin A3
iGMDRD310Everolimus2
iGMDRD211(1S,3R)-RSL33
iGMDRD901ELCPK1
iGMDRD317CCT 0181591
iGMDRD765BRD-K514902541
iGMDRD536PLX-47201
iGMDRD351GW843682X1
iGMDRD424Tamatinib2
iGMDRD456Crizotinib1
iGMDRD116CD4371
iGMDRD32Metformin1
iGMDRD486Tosedostat4
iGMDRD307Manumycin A5
iGMDRD148Pifithrin-mu1
iGMDRD512nutlin 33

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STK11

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