RB1


Summary: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RB transcriptional corepressor 1MIM:614041Ensembl:ENSG00000139687HGNC:HGNC:9884PA29513q14.2

GO terms in RB1


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0000785chromatin
CCTASGO:0000785chromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCNASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005667transcription factor complex
CCIEAGO:0005819spindle
CCIDAGO:0008024cyclin/CDK positive transcription elongation factor complex
CCTASGO:0016514SWI/SNF complex
CCIDAGO:0016605PML body
CCIBAGO:0035189Rb-E2F complex
CCIDAGO:0035189Rb-E2F complex
CCTASGO:0035189Rb-E2F complex
BPTASGO:0000082G1/S transition of mitotic cell cycle
BPTASGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001558regulation of cell growth
BPIEAGO:0001894tissue homeostasis
BPISSGO:0003180aortic valve morphogenesis
BPTASGO:0006338chromatin remodeling
BPIEAGO:0006351transcription, DNA-templated
BPNASGO:0006355regulation of transcription, DNA-templated
BPIPIGO:0006469negative regulation of protein kinase activity
BPTASGO:0007050cell cycle arrest
BPTASGO:0007093mitotic cell cycle checkpoint
BPIEPGO:0007265Ras protein signal transduction
BPIBAGO:0007346regulation of mitotic cell cycle
BPIMPGO:0007346regulation of mitotic cell cycle
BPIMPGO:0010629negative regulation of gene expression
BPIEAGO:0016032viral process
BPIBAGO:0030154cell differentiation
BPIBAGO:0030182neuron differentiation
BPNASGO:0030521androgen receptor signaling pathway
BPIMPGO:0031134sister chromatid biorientation
BPIBAGO:0031175neuron projection development
BPIEAGO:0031175neuron projection development
BPIMPGO:0034088maintenance of mitotic sister chromatid cohesion
BPIEAGO:0034349glial cell apoptotic process
BPIEAGO:0035914skeletal muscle cell differentiation
BPIEAGO:0042551neuron maturation
BPIEAGO:0043353enucleate erythrocyte differentiation
BPTASGO:0043433negative regulation of DNA-binding transcription factor activity
BPIDAGO:0043550regulation of lipid kinase activity
BPIMPGO:0045445myoblast differentiation
BPIEAGO:0045651positive regulation of macrophage differentiation
BPIMPGO:0045842positive regulation of mitotic metaphase/anaphase transition
BPIEAGO:0045879negative regulation of smoothened signaling pathway
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPTASGO:0045892negative regulation of transcription, DNA-templated
BPNASGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048565digestive tract development
BPIBAGO:0048667cell morphogenesis involved in neuron differentiation
BPIEAGO:0048667cell morphogenesis involved in neuron differentiation
BPIEAGO:0050680negative regulation of epithelial cell proliferation
BPISSGO:0050728negative regulation of inflammatory response
BPIEAGO:0051146striated muscle cell differentiation
BPIEAGO:0051301cell division
BPIEAGO:0051402neuron apoptotic process
BPIMPGO:0071459protein localization to chromosome, centromeric region
BPIEAGO:0071466cellular response to xenobiotic stimulus
BPIMPGO:0071922regulation of cohesin loading
BPTASGO:0071930negative regulation of transcription involved in G1/S transition of mitotic cell cycle
BPTASGO:0090230regulation of centromere complex assembly
BPIEAGO:0097284hepatocyte apoptotic process
BPISSGO:1903055positive regulation of extracellular matrix organization
BPISSGO:1904028positive regulation of collagen fibril organization
BPISSGO:1904761negative regulation of myofibroblast differentiation
BPIBAGO:2000134negative regulation of G1/S transition of mitotic cell cycle
BPTASGO:2000134negative regulation of G1/S transition of mitotic cell cycle
BPIDAGO:2000679positive regulation of transcription regulatory region DNA binding
MFIDAGO:0000987proximal promoter sequence-specific DNA binding
MFIBAGO:0001012RNA polymerase II regulatory region DNA binding
MFIBAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0001102RNA polymerase II activating transcription factor binding
MFIEAGO:0001102RNA polymerase II activating transcription factor binding
MFTASGO:0003677DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFNASGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:0019900kinase binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIPIGO:0042802identical protein binding
MFNASGO:0050681androgen receptor binding
MFIPIGO:0051219phosphoprotein binding
MFIPIGO:0061676importin-alpha family protein binding
MFIPIGO:0097718disordered domain specific binding

Gene expression in normal tissue: RB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RB1


DatabasePathway IDPathway Des.
biocartaarfpathwaytumor suppressor arf inhibits ribosomal biogenesis
biocartabtg2pathwaybtg family proteins and cell cycle regulation
biocartacellcyclepathwaycyclins and cell cycle regulation
biocartafaspathwayfas signaling pathway (cd95)
biocartafbw7pathwaycyclin e destruction pathway
biocartag1pathwaycell cycle: g1/s check point
biocartahcmvpathwayhuman cytomegalovirus and map kinase pathways
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartap27pathwayregulation of p27 phosphorylation during cell cycle progression
biocartap53pathwayp53 signaling pathway
biocartapmlpathwayregulation of transcriptional activity by pml
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartarbpathwayrb tumor suppressor/checkpoint signaling in response to dna damage
biocartaskp2e2fpathwaye2f1 destruction pathway
biocartatelpathwaytelomeres telomerase cellular aging and immortality
biocartatercpathwayoverview of telomerase rna component gene hterc transcriptional regulation
biocartatidpathwaychaperones modulate interferon signaling pathway
reactomeR-HSA-113501Inhibition of replication initiation of damaged DNA by RB1/E2F1
reactomeR-HSA-113501Inhibition of replication initiation of damaged DNA by RB1/E2F1
reactomeR-HSA-113510E2F mediated regulation of DNA replication
reactomeR-HSA-113510E2F mediated regulation of DNA replication
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2299718Condensation of Prophase Chromosomes
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559584Formation of Senescence-Associated Heterochromatin Foci (SAHF)
reactomeR-HSA-2559585Oncogene Induced Senescence
reactomeR-HSA-2559586DNA Damage/Telomere Stress Induced Senescence
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-68875Mitotic Prophase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8940973RUNX2 regulates osteoblast differentiation
reactomeR-HSA-8941326RUNX2 regulates bone development
reactomeR-HSA-8953897Cellular responses to external stimuli
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP179Cell Cycle
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP236Adipogenesis
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3969H19 action Rb-E2F1 signaling and CDK-?-catenin activity
wikipathwaysWP4204Tumor suppressor activity of SMARCB1
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP53ID signaling pathway
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP707DNA Damage Response
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
pidatf2_pathwayATF-2 transcription factor network
pidceramide_pathwayCeramide signaling pathway
pide2f_pathwayE2F transcription factor network
pidfoxm1pathwayFOXM1 transcription factor network
pidhes_heypathwayNotch-mediated HES/HEY network
pidp53downstreampathwayDirect p53 effectors
pidp73pathwayp73 transcription factor network
pidrb_1pathwayRegulation of retinoblastoma protein
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_BCRBCR
netpathPathway_IDID
netpathPathway_IL1IL1
netpathPathway_IL6IL6
netpathPathway_ProlactinProlactin
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
netpathPathway_TNFalphaTNFalpha

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD291AC1NS4S01
iGMDRD451Serdemetan3
iGMDRD887Compound 23 citrate2
iGMDRD727Alpelisib1
iGMDRD30917AAG1
iGMDRD440Nutlin-3A1
iGMDRD138PX 122
iGMDRD33Entinostat1
iGMDRD134Sorafenib1
iGMDRD8024-methylfasudil6
iGMDRD280CYTOCHALASIN B1
iGMDRD375GW-4058335
iGMDRD281Vinorelbine base1
iGMDRD253Vincaleukoblastine1
iGMDRD446LY 21832401
iGMDRD66Doxorubicin1
iGMDRD129SB-2167631
iGMDRD494Neopeltolide6
iGMDRD579PF7501
iGMDRD599Salermide1
iGMDRD886Compound 1541A3
iGMDRD42Vorinostat3
iGMDRD882CIL411
iGMDRD434BMS-5369242
iGMDRD6AM-5802
iGMDRD551Ponatinib1
iGMDRD917HDAC inhibitor3
iGMDRD177Teniposide5
iGMDRD211(1S,3R)-RSL31
iGMDRD536PLX-47201
iGMDRD160Cis-Platin3
iGMDRD116CD4372
iGMDRD652UNC06381
iGMDRD148Pifithrin-mu2
iGMDRD512nutlin 32
iGMDRD23Gossypol3
iGMDRD356PNU-746542
iGMDRD133Lapatinib1
iGMDRD888Compound 442
iGMDRD187BRD98762
iGMDRD468AZ6281
iGMDRD247Blebbistatin2
iGMDRD493GSK269962A1
iGMDRD568SCHEMBL150055121
iGMDRD260FQI-21
iGMDRD466Chaetocin3
iGMDRD21Fluorouracil1
iGMDRD61Kinetin riboside10
iGMDRD748PHA-6657521
iGMDRD670ML 2102
iGMDRD546BMS-7548075
iGMDRD397Pazopanib1
iGMDRD403BAY 61-36061
iGMDRD409Saracatinib1
iGMDRD76Simvastatin1
iGMDRD889Compound 7d-cis2
iGMDRD552AZD-17753
iGMDRD322FK 8668
iGMDRD367Ro 28-16752
iGMDRD662JQ-11
iGMDRD221Tamoxifen1
iGMDRD121GMX17785
iGMDRD158NSC1415405
iGMDRD137Indisulam3
iGMDRD202Curcumin2
iGMDRD103SN-382
iGMDRD123Isoevodiamine1
iGMDRD879chemotherapy1
iGMDRD154NSC237666
iGMDRD237ABT-7512
iGMDRD352PD-03259011
iGMDRD314Tanespimycin2
iGMDRD79Gemcitabine2
iGMDRD20Embelin1
iGMDRD131Erlotinib1
iGMDRD60Quinoclamine1
iGMDRD562Navitoclax4
iGMDRD577BIX012944
iGMDRD573GSK-1904529A1
iGMDRD870BRD636103
iGMDRD574Ruxolitinib1
iGMDRD441TW 373
iGMDRD318PAC-14
iGMDRD491TAE-6841
iGMDRD255SB2250022
iGMDRD181CDK4 inhibitor1
iGMDRD678Tubastatin A1
iGMDRD587CHEMBL5859511
iGMDRD136Nutlin-31
iGMDRD1008SR-II-138A6
iGMDRD300Tozasertib4
iGMDRD872BRD71375
iGMDRD414MST-3125
iGMDRD241Sunitinib1
iGMDRD68Paclitaxel1
iGMDRD271Brefeldin A4
iGMDRD499PDMP4
iGMDRD351GW843682X6
iGMDRD456Crizotinib1
iGMDRD232FTI-2771
iGMDRD382CEP-7011
iGMDRD190Nilotinib1
iGMDRD64Parbendazole2
iGMDRD399Selumetinib3
iGMDRD74Idarubicin2
iGMDRD188Piperlongumine7
iGMDRD780PP-301
iGMDRD391OSU-030121
iGMDRD224Necrostatin-11
iGMDRD506Fedratinib4
iGMDRD171Pemetrexed3
iGMDRD284Palbociclib13
iGMDRD507GSK6906931
iGMDRD152179324-69-74
iGMDRD427ABT7376
iGMDRD484Pluripotin2
iGMDRD781Sirolimus3
iGMDRD151CHM-12
iGMDRD126Tipifarnib2
iGMDRD420Leucascandrolide A2
iGMDRD245FH5351
iGMDRD442BMS-5097441
iGMDRD67PENFLURIDOL1
iGMDRD286Nsc 6328398
iGMDRD329Merck601
iGMDRD289Parthenolide2
iGMDRD705Nakiterpiosin3
iGMDRD396AS6012451
iGMDRD251ML1625
iGMDRD49Mitomycin1
iGMDRD376Tivozanib1
iGMDRD532Olaparib2
iGMDRD248BRD43541
iGMDRD940MDM2/MDMX inhibitor6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RB1

​​​​