ARID1A


Summary: This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
AT-rich interaction domain 1AMIM:603024Ensembl:ENSG00000117713HGNC:HGNC:11110PA359601p36.11

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in ARID1A


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001704formation of primary germ layer
BPIEAGO:0001843neural tube closure
BPIEAGO:0003205cardiac chamber development
BPIEAGO:0003408optic cup formation involved in camera-type eye development
BPIDAGO:0006337nucleosome disassembly
BPIDAGO:0006338chromatin remodeling
BPIEAGO:0006344maintenance of chromatin silencing
BPIEAGO:0006351transcription, DNA-templated
BPNASGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0007566embryo implantation
BPIEAGO:0019827stem cell population maintenance
BPIDAGO:0030520intracellular estrogen receptor signaling pathway
BPIDAGO:0030521androgen receptor signaling pathway
BPIEAGO:0030900forebrain development
BPTASGO:0042766nucleosome mobilization
BPIDAGO:0042921glucocorticoid receptor signaling pathway
BPIEAGO:0043044ATP-dependent chromatin remodeling
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPTASGO:0048096chromatin-mediated maintenance of transcription
BPIEAGO:0055007cardiac muscle cell differentiation
BPIEAGO:0060674placenta blood vessel development
BPHEPGO:0071277cellular response to calcium ion
BPIEAGO:1901998toxin transport
CCIDAGO:0000790nuclear chromatin
CCTASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0016514SWI/SNF complex
CCISSGO:0071564npBAF complex
CCISSGO:0071565nBAF complex
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFNASGO:0003677DNA binding
MFNASGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIPIGO:0016922nuclear receptor binding
MFIEAGO:0031491nucleosome binding

Gene expression in normal tissue: ARID1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARID1A


DatabasePathway IDPathway Des.
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3214858RMTs methylate histone arginines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
biocartahswisnfpathwaychromatin remodeling by hswi/snf atp-dependent complexes
biocartapcafpathwaythe information processing pathway at the ifn beta enhancer
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
wikipathwaysWP4204Tumor suppressor activity of SMARCB1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD1021Trastuzumab (ANXA1 high)1
iGMDRD286Nsc 6328398
iGMDRD329Merck602
iGMDRD263AACOCF33
iGMDRD245FH5351
iGMDRD402AKT Inhibitor VIII2
iGMDRD289Parthenolide3
iGMDRD705Nakiterpiosin2
iGMDRD396AS6012451
iGMDRD461VX-11e2
iGMDRD341Triacsin c2
iGMDRD945ML2142
iGMDRD605AZD64821
iGMDRD48Dexamethasone2
iGMDRD370TPCA-11
iGMDRD150RITA2
iGMDRD1036X17AAG1
iGMDRD523Cyanoquinoline, 112
iGMDRD399Selumetinib1
iGMDRD188Piperlongumine4
iGMDRD506Fedratinib6
iGMDRD369TGX-1152
iGMDRD64Parbendazole2
iGMDRD474Avrainvillamide4
iGMDRD171Pemetrexed2
iGMDRD117Docetaxel1
iGMDRD593CX-54611
iGMDRD52Rotenone2
iGMDRD152179324-69-72
iGMDRD394BX-7952
iGMDRD151CHM-12
iGMDRD126Tipifarnib7
iGMDRD420Leucascandrolide A5
iGMDRD427ABT7372
iGMDRD872BRD71377
iGMDRD1015THZ-2-102-11
iGMDRD414MST-3122
iGMDRD505Pevonedistat6
iGMDRD300Tozasertib3
iGMDRD503CMK1
iGMDRD901ELCPK2
iGMDRD486Tosedostat2
iGMDRD1020Trastuzumab2
iGMDRD345Compound 10b [PMID: 11504634]1
iGMDRD577BIX012942
iGMDRD60Quinoclamine4
iGMDRD131Erlotinib1
iGMDRD255SB2250023
iGMDRD907EZH2 inhibitor2
iGMDRD758JW-7-24-11
iGMDRD573GSK-1904529A1
iGMDRD885Compound 1102
iGMDRD318PAC-11
iGMDRD193Fqi12
iGMDRD401Afatinib2
iGMDRD348BMS-3455411
iGMDRD54Phenformin1
iGMDRD772BRD47702
iGMDRD678Tubastatin A1
iGMDRD971PARP inhibitor2
iGMDRD871BRD63686
iGMDRD322FK 8663
iGMDRD534BRD14291
iGMDRD137Indisulam2
iGMDRD158NSC1415404
iGMDRD121GMX17786
iGMDRD202Curcumin3
iGMDRD5Tyrphostin AG 14785
iGMDRD221Tamoxifen4
iGMDRD215CCT0070931
iGMDRD77Itraconazole5
iGMDRD219Bax channel blocker2
iGMDRD237ABT-7512
iGMDRD698Neratinib4
iGMDRD123Isoevodiamine2
iGMDRD154NSC237662
iGMDRD883CIL55A1
iGMDRD1002rTRAIL2
iGMDRD475BX 9121
iGMDRD392Masitinib1
iGMDRD719IOX21
iGMDRD560MK-22063
iGMDRD79Gemcitabine5
iGMDRD730Kahalalide F3
iGMDRD23Gossypol2
iGMDRD260FQI-22
iGMDRD568SCHEMBL150055121
iGMDRD187BRD98763
iGMDRD226ML0062
iGMDRD326Belinostat (PXD101)1
iGMDRD61Kinetin riboside5
iGMDRD639YK 4-2792
iGMDRD466Chaetocin1
iGMDRD470Trametinib1
iGMDRD409Saracatinib1
iGMDRD433Lexibulin4
iGMDRD12Bicalutamide1
iGMDRD889Compound 7d-cis2
iGMDRD546BMS-7548074
iGMDRD476WH-4-0231
iGMDRD483SCH-5290744
iGMDRD269Purmorphamine2
iGMDRD246NPC263
iGMDRD191FMK1
iGMDRD42Vorinostat3
iGMDRD267Oligomycin A3
iGMDRD231Importazole3
iGMDRD481Dactolisib3
iGMDRD57Chloropentafluorobenzene4
iGMDRD177Teniposide5
iGMDRD84Lovastatin acid2
iGMDRD424Tamatinib2
iGMDRD116CD4372
iGMDRD652UNC06381
iGMDRD100Zebularine2
iGMDRD692SB5908851
iGMDRD451Serdemetan4
iGMDRD268Cerulenin1
iGMDRD454JNK Inhibitor VIII1
iGMDRD270Ciclosporin2
iGMDRD8024-methylfasudil1
iGMDRD440Nutlin-3A1
iGMDRD498GW441756X2
iGMDRD446LY 21832403
iGMDRD908EZH2 inhibitor in RAS wt1
iGMDRD280CYTOCHALASIN B1
iGMDRD375GW-4058332
iGMDRD599Salermide2
iGMDRD144NSC953977
iGMDRD462OSI-906 (Linsitinib)1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARID1A

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