ARID1A
Summary: This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
AT-rich interaction domain 1A | MIM:603024 | Ensembl:ENSG00000117713 | HGNC:HGNC:11110 | PA35960 | 1p36.11 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in ARID1A
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | IEA | GO:0001704 | formation of primary germ layer |
BP | IEA | GO:0001843 | neural tube closure |
BP | IEA | GO:0003205 | cardiac chamber development |
BP | IEA | GO:0003408 | optic cup formation involved in camera-type eye development |
BP | IDA | GO:0006337 | nucleosome disassembly |
BP | IDA | GO:0006338 | chromatin remodeling |
BP | IEA | GO:0006344 | maintenance of chromatin silencing |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | NAS | GO:0006357 | regulation of transcription by RNA polymerase II |
BP | IEA | GO:0007566 | embryo implantation |
BP | IEA | GO:0019827 | stem cell population maintenance |
BP | IDA | GO:0030520 | intracellular estrogen receptor signaling pathway |
BP | IDA | GO:0030521 | androgen receptor signaling pathway |
BP | IEA | GO:0030900 | forebrain development |
BP | TAS | GO:0042766 | nucleosome mobilization |
BP | IDA | GO:0042921 | glucocorticoid receptor signaling pathway |
BP | IEA | GO:0043044 | ATP-dependent chromatin remodeling |
BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
BP | TAS | GO:0048096 | chromatin-mediated maintenance of transcription |
BP | IEA | GO:0055007 | cardiac muscle cell differentiation |
BP | IEA | GO:0060674 | placenta blood vessel development |
BP | HEP | GO:0071277 | cellular response to calcium ion |
BP | IEA | GO:1901998 | toxin transport |
CC | IDA | GO:0000790 | nuclear chromatin |
CC | TAS | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
CC | IDA | GO:0016514 | SWI/SNF complex |
CC | ISS | GO:0071564 | npBAF complex |
CC | ISS | GO:0071565 | nBAF complex |
MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | IDA | GO:0003677 | DNA binding |
MF | NAS | GO:0003677 | DNA binding |
MF | NAS | GO:0003713 | transcription coactivator activity |
MF | IPI | GO:0005515 | protein binding |
MF | IPI | GO:0016922 | nuclear receptor binding |
MF | IEA | GO:0031491 | nucleosome binding |
Gene expression in normal tissue: ARID1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARID1A
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-212436 | Generic Transcription Pathway |
reactome | R-HSA-3214858 | RMTs methylate histone arginines |
reactome | R-HSA-3247509 | Chromatin modifying enzymes |
reactome | R-HSA-4839726 | Chromatin organization |
reactome | R-HSA-73857 | RNA Polymerase II Transcription |
reactome | R-HSA-74160 | Gene expression (Transcription) |
reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
reactome | R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
biocarta | hswisnfpathway | chromatin remodeling by hswi/snf atp-dependent complexes |
biocarta | pcafpathway | the information processing pathway at the ifn beta enhancer |
kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
wikipathways | WP4204 | Tumor suppressor activity of SMARCB1 |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD1021 | Trastuzumab (ANXA1 high) | 1 |
iGMDRD286 | Nsc 632839 | 8 |
iGMDRD329 | Merck60 | 2 |
iGMDRD263 | AACOCF3 | 3 |
iGMDRD245 | FH535 | 1 |
iGMDRD402 | AKT Inhibitor VIII | 2 |
iGMDRD289 | Parthenolide | 3 |
iGMDRD705 | Nakiterpiosin | 2 |
iGMDRD396 | AS601245 | 1 |
iGMDRD461 | VX-11e | 2 |
iGMDRD341 | Triacsin c | 2 |
iGMDRD945 | ML214 | 2 |
iGMDRD605 | AZD6482 | 1 |
iGMDRD48 | Dexamethasone | 2 |
iGMDRD370 | TPCA-1 | 1 |
iGMDRD150 | RITA | 2 |
iGMDRD1036 | X17AAG | 1 |
iGMDRD523 | Cyanoquinoline, 11 | 2 |
iGMDRD399 | Selumetinib | 1 |
iGMDRD188 | Piperlongumine | 4 |
iGMDRD506 | Fedratinib | 6 |
iGMDRD369 | TGX-115 | 2 |
iGMDRD64 | Parbendazole | 2 |
iGMDRD474 | Avrainvillamide | 4 |
iGMDRD171 | Pemetrexed | 2 |
iGMDRD117 | Docetaxel | 1 |
iGMDRD593 | CX-5461 | 1 |
iGMDRD52 | Rotenone | 2 |
iGMDRD152 | 179324-69-7 | 2 |
iGMDRD394 | BX-795 | 2 |
iGMDRD151 | CHM-1 | 2 |
iGMDRD126 | Tipifarnib | 7 |
iGMDRD420 | Leucascandrolide A | 5 |
iGMDRD427 | ABT737 | 2 |
iGMDRD872 | BRD7137 | 7 |
iGMDRD1015 | THZ-2-102-1 | 1 |
iGMDRD414 | MST-312 | 2 |
iGMDRD505 | Pevonedistat | 6 |
iGMDRD300 | Tozasertib | 3 |
iGMDRD503 | CMK | 1 |
iGMDRD901 | ELCPK | 2 |
iGMDRD486 | Tosedostat | 2 |
iGMDRD1020 | Trastuzumab | 2 |
iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
iGMDRD577 | BIX01294 | 2 |
iGMDRD60 | Quinoclamine | 4 |
iGMDRD131 | Erlotinib | 1 |
iGMDRD255 | SB225002 | 3 |
iGMDRD907 | EZH2 inhibitor | 2 |
iGMDRD758 | JW-7-24-1 | 1 |
iGMDRD573 | GSK-1904529A | 1 |
iGMDRD885 | Compound 110 | 2 |
iGMDRD318 | PAC-1 | 1 |
iGMDRD193 | Fqi1 | 2 |
iGMDRD401 | Afatinib | 2 |
iGMDRD348 | BMS-345541 | 1 |
iGMDRD54 | Phenformin | 1 |
iGMDRD772 | BRD4770 | 2 |
iGMDRD678 | Tubastatin A | 1 |
iGMDRD971 | PARP inhibitor | 2 |
iGMDRD871 | BRD6368 | 6 |
iGMDRD322 | FK 866 | 3 |
iGMDRD534 | BRD1429 | 1 |
iGMDRD137 | Indisulam | 2 |
iGMDRD158 | NSC141540 | 4 |
iGMDRD121 | GMX1778 | 6 |
iGMDRD202 | Curcumin | 3 |
iGMDRD5 | Tyrphostin AG 1478 | 5 |
iGMDRD221 | Tamoxifen | 4 |
iGMDRD215 | CCT007093 | 1 |
iGMDRD77 | Itraconazole | 5 |
iGMDRD219 | Bax channel blocker | 2 |
iGMDRD237 | ABT-751 | 2 |
iGMDRD698 | Neratinib | 4 |
iGMDRD123 | Isoevodiamine | 2 |
iGMDRD154 | NSC23766 | 2 |
iGMDRD883 | CIL55A | 1 |
iGMDRD1002 | rTRAIL | 2 |
iGMDRD475 | BX 912 | 1 |
iGMDRD392 | Masitinib | 1 |
iGMDRD719 | IOX2 | 1 |
iGMDRD560 | MK-2206 | 3 |
iGMDRD79 | Gemcitabine | 5 |
iGMDRD730 | Kahalalide F | 3 |
iGMDRD23 | Gossypol | 2 |
iGMDRD260 | FQI-2 | 2 |
iGMDRD568 | SCHEMBL15005512 | 1 |
iGMDRD187 | BRD9876 | 3 |
iGMDRD226 | ML006 | 2 |
iGMDRD326 | Belinostat (PXD101) | 1 |
iGMDRD61 | Kinetin riboside | 5 |
iGMDRD639 | YK 4-279 | 2 |
iGMDRD466 | Chaetocin | 1 |
iGMDRD470 | Trametinib | 1 |
iGMDRD409 | Saracatinib | 1 |
iGMDRD433 | Lexibulin | 4 |
iGMDRD12 | Bicalutamide | 1 |
iGMDRD889 | Compound 7d-cis | 2 |
iGMDRD546 | BMS-754807 | 4 |
iGMDRD476 | WH-4-023 | 1 |
iGMDRD483 | SCH-529074 | 4 |
iGMDRD269 | Purmorphamine | 2 |
iGMDRD246 | NPC26 | 3 |
iGMDRD191 | FMK | 1 |
iGMDRD42 | Vorinostat | 3 |
iGMDRD267 | Oligomycin A | 3 |
iGMDRD231 | Importazole | 3 |
iGMDRD481 | Dactolisib | 3 |
iGMDRD57 | Chloropentafluorobenzene | 4 |
iGMDRD177 | Teniposide | 5 |
iGMDRD84 | Lovastatin acid | 2 |
iGMDRD424 | Tamatinib | 2 |
iGMDRD116 | CD437 | 2 |
iGMDRD652 | UNC0638 | 1 |
iGMDRD100 | Zebularine | 2 |
iGMDRD692 | SB590885 | 1 |
iGMDRD451 | Serdemetan | 4 |
iGMDRD268 | Cerulenin | 1 |
iGMDRD454 | JNK Inhibitor VIII | 1 |
iGMDRD270 | Ciclosporin | 2 |
iGMDRD802 | 4-methylfasudil | 1 |
iGMDRD440 | Nutlin-3A | 1 |
iGMDRD498 | GW441756X | 2 |
iGMDRD446 | LY 2183240 | 3 |
iGMDRD908 | EZH2 inhibitor in RAS wt | 1 |
iGMDRD280 | CYTOCHALASIN B | 1 |
iGMDRD375 | GW-405833 | 2 |
iGMDRD599 | Salermide | 2 |
iGMDRD144 | NSC95397 | 7 |
iGMDRD462 | OSI-906 (Linsitinib) | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARID1A