EGFR


Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
epidermal growth factor receptorMIM:131550Ensembl:ENSG00000146648HGNC:HGNC:3236PA73607p11.2

GO terms in EGFR


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0000139Golgi membrane
CCNASGO:0005615extracellular space
CCIDAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005768endosome
CCIDAGO:0005768endosome
CCIEAGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCHDAGO:0005925focal adhesion
CCIBAGO:0009925basal plasma membrane
CCIDAGO:0009986cell surface
CCIDAGO:0010008endosome membrane
CCIDAGO:0016020membrane
CCIEAGO:0016021integral component of membrane
CCIDAGO:0016323basolateral plasma membrane
CCIEAGO:0016324apical plasma membrane
CCTASGO:0030122AP-2 adaptor complex
CCTASGO:0030665clathrin-coated vesicle membrane
CCIDAGO:0031901early endosome membrane
CCIEAGO:0031965nuclear membrane
CCIDAGO:0032991protein-containing complex
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex
CCIDAGO:0045121membrane raft
CCIEAGO:0045202synapse
CCIEAGO:0048471perinuclear region of cytoplasm
CCISSGO:0070435Shc-EGFR complex
CCIDAGO:0097489multivesicular body, internal vesicle lumen
BPTASGO:0000165MAPK cascade
BPIEAGO:0000186activation of MAPKK activity
BPNASGO:0001503ossification
BPIEAGO:0001892embryonic placenta development
BPIDAGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0001942hair follicle development
BPTASGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006412translation
BPIEAGO:0006970response to osmotic stress
BPIDAGO:0007165signal transduction
BPTASGO:0007165signal transduction
BPIDAGO:0007166cell surface receptor signaling pathway
BPIDAGO:0007173epidermal growth factor receptor signaling pathway
BPIMPGO:0007173epidermal growth factor receptor signaling pathway
BPTASGO:0007173epidermal growth factor receptor signaling pathway
BPTASGO:0007202activation of phospholipase C activity
BPIBAGO:0007275multicellular organism development
BPIEAGO:0007435salivary gland morphogenesis
BPIEAGO:0007494midgut development
BPISSGO:0007611learning or memory
BPIEAGO:0007623circadian rhythm
BPIDAGO:0008283cell proliferation
BPIDAGO:0008284positive regulation of cell proliferation
BPIMPGO:0008284positive regulation of cell proliferation
BPIBAGO:0009968negative regulation of signal transduction
BPIDAGO:0010750positive regulation of nitric oxide mediated signal transduction
BPIEAGO:0010960magnesium ion homeostasis
BPIMPGO:0014066regulation of phosphatidylinositol 3-kinase signaling
BPIEAGO:0016101diterpenoid metabolic process
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0021795cerebral cortex cell migration
BPIBAGO:0030154cell differentiation
BPIDAGO:0030307positive regulation of cell growth
BPIEAGO:0030324lung development
BPIMPGO:0030335positive regulation of cell migration
BPIDAGO:0031659positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
BPIEAGO:0032930positive regulation of superoxide anion generation
BPIMPGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIEAGO:0033590response to cobalamin
BPIEAGO:0033594response to hydroxyisoflavone
BPIBAGO:0033674positive regulation of kinase activity
BPIMPGO:0034614cellular response to reactive oxygen species
BPIMPGO:0038083peptidyl-tyrosine autophosphorylation
BPTASGO:0038083peptidyl-tyrosine autophosphorylation
BPTASGO:0038128ERBB2 signaling pathway
BPTASGO:0042059negative regulation of epidermal growth factor receptor signaling pathway
BPIEAGO:0042060wound healing
BPIDAGO:0042177negative regulation of protein catabolic process
BPIDAGO:0042327positive regulation of phosphorylation
BPIEAGO:0042698ovulation cycle
BPIEAGO:0042743hydrogen peroxide metabolic process
BPTASGO:0043006activation of phospholipase A2 activity by calcium-mediated signaling
BPIBAGO:0043066negative regulation of apoptotic process
BPIMPGO:0043066negative regulation of apoptotic process
BPIDAGO:0043406positive regulation of MAP kinase activity
BPIBAGO:0043410positive regulation of MAPK cascade
BPIEAGO:0043586tongue development
BPIDAGO:0045739positive regulation of DNA repair
BPIDAGO:0045740positive regulation of DNA replication
BPTASGO:0045746negative regulation of Notch signaling pathway
BPIEAGO:0045780positive regulation of bone resorption
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0045907positive regulation of vasoconstriction
BPIEAGO:0045930negative regulation of mitotic cell cycle
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0046328regulation of JNK cascade
BPIEAGO:0046718viral entry into host cell
BPIMPGO:0046777protein autophosphorylation
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPIEAGO:0048143astrocyte activation
BPIEAGO:0048146positive regulation of fibroblast proliferation
BPIEAGO:0048546digestive tract morphogenesis
BPIEAGO:0048661positive regulation of smooth muscle cell proliferation
BPIEAGO:0048812neuron projection morphogenesis
BPIDAGO:0050679positive regulation of epithelial cell proliferation
BPIEAGO:0050729positive regulation of inflammatory response
BPIMPGO:0050730regulation of peptidyl-tyrosine phosphorylation
BPIDAGO:0050999regulation of nitric-oxide synthase activity
BPTASGO:0051205protein insertion into membrane
BPIEAGO:0051592response to calcium ion
BPIMPGO:0051897positive regulation of protein kinase B signaling
BPTASGO:0051897positive regulation of protein kinase B signaling
BPIEAGO:0051968positive regulation of synaptic transmission, glutamatergic
BPIEAGO:0060571morphogenesis of an epithelial fold
BPTASGO:0061024membrane organization
BPIEAGO:0061029eyelid development in camera-type eye
BPIDAGO:0070141response to UV-A
BPIMPGO:0070372regulation of ERK1 and ERK2 cascade
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIEAGO:0071230cellular response to amino acid stimulus
BPIEAGO:0071260cellular response to mechanical stimulus
BPIMPGO:0071276cellular response to cadmium ion
BPISSGO:0071364cellular response to epidermal growth factor stimulus
BPIDAGO:0071392cellular response to estradiol stimulus
BPIEAGO:0071549cellular response to dexamethasone stimulus
BPIMPGO:0090263positive regulation of canonical Wnt signaling pathway
BPIEAGO:0097421liver regeneration
BPIEAGO:0097755positive regulation of blood vessel diameter
BPIMPGO:0098609cell-cell adhesion
BPIDAGO:1900020positive regulation of protein kinase C activity
BPTASGO:1901185negative regulation of ERBB signaling pathway
BPIMPGO:1901224positive regulation of NIK/NF-kappaB signaling
BPIEAGO:1902722positive regulation of prolactin secretion
BPIDAGO:1903078positive regulation of protein localization to plasma membrane
BPIMPGO:1903800positive regulation of production of miRNAs involved in gene silencing by miRNA
BPIMPGO:1905208negative regulation of cardiocyte differentiation
BPTASGO:2000145regulation of cell motility
MFIEAGO:0001618virus receptor activity
MFIDAGO:0003682chromatin binding
MFNASGO:0003690double-stranded DNA binding
MFIBAGO:0004709MAP kinase kinase kinase activity
MFNASGO:0004709MAP kinase kinase kinase activity
MFEXPGO:0004713protein tyrosine kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIDAGO:0004713protein tyrosine kinase activity
MFIMPGO:0004713protein tyrosine kinase activity
MFTASGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFTASGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIDAGO:0004888transmembrane signaling receptor activity
MFIBAGO:0005006epidermal growth factor-activated receptor activity
MFIDAGO:0005006epidermal growth factor-activated receptor activity
MFIMPGO:0005006epidermal growth factor-activated receptor activity
MFNASGO:0005006epidermal growth factor-activated receptor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIEAGO:0005178integrin binding
MFIPIGO:0005515protein binding
MFIEAGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019899enzyme binding
MFIEAGO:0019901protein kinase binding
MFIPIGO:0019903protein phosphatase binding
MFIDAGO:0030235nitric-oxide synthase regulator activity
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIPIGO:0042802identical protein binding
MFHDAGO:0045296cadherin binding
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MFIDAGO:0046982protein heterodimerization activity
MFIBAGO:0048408epidermal growth factor binding
MFIEAGO:0048408epidermal growth factor binding
MFIDAGO:0051015actin filament binding

Gene expression in normal tissue: EGFR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EGFR


DatabasePathway IDPathway Des.
smpdbSMP00463Phosphatidylinositol Phosphate Metabolism
smpdbSMP00472Erlotinib Action Pathway
smpdbSMP00473Gefitinib Action Pathway
smpdbSMP00474Cetuximab Action Pathway
smpdbSMP00475Panitumumab Action Pathway
smpdbSMP00476Trastuzumab Action Pathway
smpdbSMP00582Joubert syndrome
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP2002miR-targeted genes in epithelium - TarBase
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2363Gastric Cancer Network 2
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP2593JAK-STAT
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP2868TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
wikipathwaysWP2870Extracellular vesicle-mediated signaling in recipient cells
wikipathwaysWP2873Aryl Hydrocarbon Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3680Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3853ERK Pathway in Huntington,s Disease
wikipathwaysWP3927BMP Signaling Pathway in Eyelid Development
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4086Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host
wikipathwaysWP4223Ras Signaling
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP673ErbB Signaling Pathway
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
pidarf6_pathwayArf6 signaling events
pidecadherin_keratinocyte_pathwayE-cadherin signaling in keratinocytes
pidecadherin_stabilization_pathwayStabilization and expansion of the E-cadherin adherens junction
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb1_internalization_pathwayInternalization of ErbB1
piderbb_network_pathwayErbB receptor signaling network
pidet_egfrpathwayEGFR-dependent Endothelin signaling events
pidlysophospholipid_pathwayLPA receptor mediated events
pidp53downstreampathwayDirect p53 effectors
pidptp1bpathwaySignaling events mediated by PTP1B
pidshp2_pathwaySHP2 signaling
pidsyndecan_3_pathwaySyndecan-3-mediated signaling events
pidtcptp_pathwaySignaling events mediated by TCPTP
pidtelomerasepathwayRegulation of Telomerase
pidtxa2pathwayThromboxane A2 receptor signaling
pidupa_upar_pathwayUrokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
pharmgkbPA154426903Erlotinib Pathway, Pharmacokinetics
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
biocartaagrpathwayagrin in postsynaptic differentiation
biocartaat1rpathwayangiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartacblpathwaycbl mediated ligand-induced downregulation of egf receptors pathway
biocartaegfpathwayegf signaling pathway
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamcalpainpathwaymcalpain and friends in cell motility
biocartasmrtepathwaymap kinase inactivation of smrt corepressor
biocartasprypathwaysprouty regulation of tyrosine kinase signals
biocartatffpathwaytrefoil factors initiate mucosal healing
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1251932PLCG1 events in ERBB2 signaling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1643713Signaling by EGFR in Cancer
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-179812GRB2 events in EGFR signaling
reactomeR-HSA-180292GAB1 signalosome
reactomeR-HSA-180336SHC1 events in EGFR signaling
reactomeR-HSA-182971EGFR downregulation
reactomeR-HSA-1963640GRB2 events in ERBB2 signaling
reactomeR-HSA-1963642PI3K events in ERBB2 signaling
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212718EGFR interacts with phospholipase C-gamma
reactomeR-HSA-2179392EGFR Transactivation by Gastrin
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445144Signal transduction by L1
reactomeR-HSA-5637810Constitutive Signaling by EGFRvIII
reactomeR-HSA-5637812Signaling by EGFRvIII in Cancer
reactomeR-HSA-5637815Signaling by Ligand-Responsive EGFR Variants in Cancer
reactomeR-HSA-5638302Signaling by Overexpressed Wild-Type EGFR in Cancer
reactomeR-HSA-5638303Inhibition of Signaling by Overexpressed EGFR
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6785631ERBB2 Regulates Cell Motility
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-881907Gastrin-CREB signalling pathway via PKC and MAPK
reactomeR-HSA-8847993ERBB2 Activates PTK6 Signaling
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
reactomeR-HSA-8856828Clathrin-mediated endocytosis
reactomeR-HSA-8857538PTK6 promotes HIF1A stabilization
reactomeR-HSA-8863795Downregulation of ERBB2 signaling
reactomeR-HSA-8864260Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
reactomeR-HSA-8866910TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9013507NOTCH3 Activation and Transmission of Signal to the Nucleus
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_AndrogenReceptorAndrogenReceptor
netpathPathway_EGFR1EGFR1
netpathPathway_GastrinGastrin
netpathPathway_LeptinLeptin
netpathPathway_ProlactinProlactin
netpathPathway_RAGERAGE
netpathPathway_TNFalphaTNFalpha
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04520Adherens junction - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD772BRD47702
iGMDRD659Avagacestat (BMS-708163)1
iGMDRD229B021
iGMDRD554CHEMBL14341375
iGMDRD97Bexarotene1
iGMDRD136Nutlin-31
iGMDRD112Methotrexate1
iGMDRD239Dasatinib1
iGMDRD678Tubastatin A1
iGMDRD193Fqi11
iGMDRD201SKI II4
iGMDRD608Refametinib1
iGMDRD401Afatinib206
iGMDRD109Gefitinib231
iGMDRD613CHEMBL2581483
iGMDRD255SB2250021
iGMDRD870BRD636107
iGMDRD318PAC-11
iGMDRD441TW 372
iGMDRD885Compound 1103
iGMDRD782DC-45-A210
iGMDRD573GSK-1904529A2
iGMDRD398Sepantronium2
iGMDRD577BIX012949
iGMDRD312Pelitinib3
iGMDRD131Erlotinib199
iGMDRD60Quinoclamine1
iGMDRD898EGFR mAb inhibitor2
iGMDRD930irreversible EGFR T790M inhibitor5
iGMDRD382CEP-7011
iGMDRD232FTI-2771
iGMDRD299ICL 6704
iGMDRD863BRD-K976511421
iGMDRD912first-generation and irreversible EGFR TKIs3
iGMDRD492HBX-411081
iGMDRD374Zibotentan (ZD4054)1
iGMDRD954Nimotuzumab4
iGMDRD271Brefeldin A3
iGMDRD959novel anti-EGFR mAbs2
iGMDRD504Obatoclax1
iGMDRD389SB5253341
iGMDRD62Platinum1
iGMDRD931irreversible EGFR TKIs11
iGMDRD414MST-3123
iGMDRD82Quiflapon6
iGMDRD894EGFR inhibitor6
iGMDRD300Tozasertib1
iGMDRD472PF-5622711
iGMDRD505Pevonedistat13
iGMDRD721HM617132
iGMDRD895EGFR inhibitor 1st gen8
iGMDRD1013Sym0044
iGMDRD126Tipifarnib9
iGMDRD899EGFR TK inhibitor16
iGMDRD781Sirolimus6
iGMDRD283Bosutinib2
iGMDRD417XL-6471
iGMDRD316N9-Isopropyl-olomoucine6
iGMDRD107Valdecoxib1
iGMDRD675Kinome_36291
iGMDRD394BX-7952
iGMDRD507GSK6906931
iGMDRD474Avrainvillamide1
iGMDRD762AZD-92913
iGMDRD52Rotenone4
iGMDRD44Temozolomide1
iGMDRD284Palbociclib1
iGMDRD171Pemetrexed4
iGMDRD117Docetaxel4
iGMDRD780PP-306
iGMDRD506Fedratinib1
iGMDRD399Selumetinib4
iGMDRD188Piperlongumine4
iGMDRD41Imatinib1
iGMDRD896EGFR inhibitor 2nd gen4
iGMDRD334MEK Inhibitor (alone or in combination)24
iGMDRD190Nilotinib1
iGMDRD64Parbendazole2
iGMDRD369TGX-1154
iGMDRD324CI-10401
iGMDRD248BRD43541
iGMDRD330BRD41321
iGMDRD405PIK-751
iGMDRD523Cyanoquinoline, 117
iGMDRD594AZD-80551
iGMDRD532Olaparib2
iGMDRD341Triacsin c1
iGMDRD821TAK-7884
iGMDRD184IPA-31
iGMDRD467Motesanib1
iGMDRD402AKT Inhibitor VIII1
iGMDRD251ML1624
iGMDRD742Apicidin1
iGMDRD396AS6012451
iGMDRD327LBH-5891
iGMDRD286Nsc 6328391
iGMDRD599Salermide3
iGMDRD763Osimertinib16
iGMDRD354Midostaurin1
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD144NSC953979
iGMDRD797ISOX DUAL4
iGMDRD446LY 21832406
iGMDRD375GW-40583313
iGMDRD33Entinostat1
iGMDRD138PX 123
iGMDRD30917AAG1
iGMDRD846BRD-K246903021
iGMDRD887Compound 23 citrate1
iGMDRD453GW25801
iGMDRD451Serdemetan1
iGMDRD447Dacomitinib21
iGMDRD512nutlin 312
iGMDRD792Cetuximab76
iGMDRD735CO-1686 (AVL-301)6
iGMDRD307Manumycin A1
iGMDRD424Tamatinib3
iGMDRD160Cis-Platin1
iGMDRD116CD4373
iGMDRD125BIRB-7961
iGMDRD627BRD-K161474741
iGMDRD536PLX-47201
iGMDRD765BRD-K514902541
iGMDRD6044449-51-81
iGMDRD450JNJ-268541651
iGMDRD211(1S,3R)-RSL32
iGMDRD386TAK-7151
iGMDRD267Oligomycin A3
iGMDRD231Importazole2
iGMDRD333MEK Inhibitor1
iGMDRD434BMS-5369241
iGMDRD6AM-5805
iGMDRD1030Tyrosine kinase inhibitor7
iGMDRD967Panitumumab13
iGMDRD837Bevacizumab1
iGMDRD946ML3201
iGMDRD42Vorinostat4
iGMDRD695FR-1802042
iGMDRD886Compound 1541A5
iGMDRD749ZINC67184531
iGMDRD425ERASTIN3
iGMDRD866BRD18125
iGMDRD12Bicalutamide1
iGMDRD897EGFR inhibitor 3rd gen8
iGMDRD433Lexibulin2
iGMDRD409Saracatinib1
iGMDRD1001Rindopepimut2
iGMDRD408AEE7881
iGMDRD670ML 2103
iGMDRD1Nicotin-Amide1
iGMDRD546BMS-7548072
iGMDRD61Kinetin riboside6
iGMDRD21Fluorouracil1
iGMDRD639YK 4-2793
iGMDRD358Semagacestat2
iGMDRD1593-Chloro-L-alanine1
iGMDRD778SCHEMBL135867081
iGMDRD466Chaetocin1
iGMDRD470Trametinib1
iGMDRD920HSP90 inhibitor26
iGMDRD816anti-EGFR mAbs2
iGMDRD888Compound 443
iGMDRD133Lapatinib2
iGMDRD356PNU-746546
iGMDRD584VER 1550082
iGMDRD79Gemcitabine2
iGMDRD27WHI-P972
iGMDRD237ABT-7511
iGMDRD219Bax channel blocker1
iGMDRD698Neratinib1
iGMDRD352PD-03259012
iGMDRD548Marinopyrrole A1
iGMDRD154NSC237661
iGMDRD1002rTRAIL1
iGMDRD240Vandetanib1
iGMDRD5Tyrphostin AG 14787
iGMDRD293Bleomycin1
iGMDRD121GMX17788
iGMDRD137Indisulam1
iGMDRD158NSC1415405
iGMDRD103SN-384
iGMDRD672Alectinib1
iGMDRD372TGX 2211
iGMDRD77Itraconazole1
iGMDRD16CICLOPIROX1
iGMDRD662JQ-13
iGMDRD664Dinaciclib1
iGMDRD322FK 8666
iGMDRD421AZD77621
iGMDRD147Prima-12

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EGFR

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