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TP53

Summary: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
tumor protein p53	MIM:191170	Ensembl:ENSG00000141510	HGNC:HGNC:11998	PA36679	17p13.1

Gene Categories:

RNA DIRECTED DNA POLYMERASE DNA REPAIR DRUGGABLE GENOME HISTONE MODIFICATION CLINICALLY ACTIONABLE TRANSCRIPTION FACTOR COMPLEX TRANSCRIPTION FACTOR BINDING TUMOR SUPPRESSOR DRUG RESISTANCE

GO terms in TP53

Term Type	Evidence Type	GO Term ID	GO Des.
BP	ISS	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IDA	GO:0000733	DNA strand renaturation
BP	TAS	GO:0006284	base-excision repair
BP	IMP	GO:0006289	nucleotide-excision repair
BP	IDA	GO:0006355	regulation of transcription, DNA-templated
BP	IMP	GO:0006355	regulation of transcription, DNA-templated
BP	IMP	GO:0006914	autophagy
BP	IDA	GO:0006974	cellular response to DNA damage stimulus
BP	IMP	GO:0006974	cellular response to DNA damage stimulus
BP	IMP	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BP	TAS	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BP	IDA	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
BP	IMP	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
BP	IDA	GO:0006983	ER overload response
BP	IDA	GO:0007050	cell cycle arrest
BP	IMP	GO:0007050	cell cycle arrest
BP	IEP	GO:0007265	Ras protein signal transduction
BP	IMP	GO:0007275	multicellular organism development
BP	IMP	GO:0007569	cell aging
BP	IDA	GO:0008104	protein localization
BP	TAS	GO:0008283	cell proliferation
BP	IDA	GO:0008285	negative regulation of cell proliferation
BP	IMP	GO:0008285	negative regulation of cell proliferation
BP	ISS	GO:0008285	negative regulation of cell proliferation
BP	ISS	GO:0008340	determination of adult lifespan
BP	IMP	GO:0009299	mRNA transcription
BP	IMP	GO:0010332	response to gamma radiation
BP	IDA	GO:0010628	positive regulation of gene expression
BP	IMP	GO:0010628	positive regulation of gene expression
BP	ISS	GO:0010628	positive regulation of gene expression
BP	IMP	GO:0016032	viral process
BP	TAS	GO:0016579	protein deubiquitination
BP	TAS	GO:0019221	cytokine-mediated signaling pathway
BP	TAS	GO:0030154	cell differentiation
BP	IMP	GO:0030308	negative regulation of cell growth
BP	IDA	GO:0030330	DNA damage response, signal transduction by p53 class mediator
BP	IMP	GO:0030330	DNA damage response, signal transduction by p53 class mediator
BP	IDA	GO:0031497	chromatin assembly
BP	IMP	GO:0031571	mitotic G1 DNA damage checkpoint
BP	IDA	GO:0032461	positive regulation of protein oligomerization
BP	IDA	GO:0034644	cellular response to UV
BP	IEP	GO:0035690	cellular response to drug
BP	IDA	GO:0042149	cellular response to glucose starvation
BP	IDA	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BP	IMP	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BP	IDA	GO:0042981	regulation of apoptotic process
BP	TAS	GO:0042981	regulation of apoptotic process
BP	IDA	GO:0043065	positive regulation of apoptotic process
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	ISS	GO:0043153	entrainment of circadian clock by photoperiod
BP	IDA	GO:0045892	negative regulation of transcription, DNA-templated
BP	IMP	GO:0045892	negative regulation of transcription, DNA-templated
BP	ISS	GO:0045892	negative regulation of transcription, DNA-templated
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IMP	GO:0045893	positive regulation of transcription, DNA-templated
BP	IDA	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
BP	IDA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IGI	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IMP	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IEP	GO:0046677	response to antibiotic
BP	TAS	GO:0046827	positive regulation of protein export from nucleus
BP	TAS	GO:0046902	regulation of mitochondrial membrane permeability
BP	IMP	GO:0048147	negative regulation of fibroblast proliferation
BP	ISS	GO:0048512	circadian behavior
BP	ISS	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
BP	TAS	GO:0051097	negative regulation of helicase activity
BP	IEA	GO:0051123	RNA polymerase II transcriptional preinitiation complex assembly
BP	TAS	GO:0051262	protein tetramerization
BP	IMP	GO:0051289	protein homotetramerization
BP	IDA	GO:0051974	negative regulation of telomerase activity
BP	IDA	GO:0065003	protein-containing complex assembly
BP	ISS	GO:0070245	positive regulation of thymocyte apoptotic process
BP	IDA	GO:0071158	positive regulation of cell cycle arrest
BP	IMP	GO:0071158	positive regulation of cell cycle arrest
BP	IEP	GO:0071456	cellular response to hypoxia
BP	IMP	GO:0071479	cellular response to ionizing radiation
BP	IDA	GO:0071480	cellular response to gamma radiation
BP	IDA	GO:0072331	signal transduction by p53 class mediator
BP	IMP	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
BP	IDA	GO:0072717	cellular response to actinomycin D
BP	IDA	GO:0090200	positive regulation of release of cytochrome c from mitochondria
BP	IMP	GO:0090399	replicative senescence
BP	IMP	GO:0090403	oxidative stress-induced premature senescence
BP	TAS	GO:0097193	intrinsic apoptotic signaling pathway
BP	IDA	GO:0097252	oligodendrocyte apoptotic process
BP	IMP	GO:1900119	positive regulation of execution phase of apoptosis
BP	TAS	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BP	TAS	GO:1901796	regulation of signal transduction by p53 class mediator
BP	TAS	GO:1902749	regulation of cell cycle G2/M phase transition
BP	IDA	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II
BP	ISS	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
BP	IMP	GO:2000379	positive regulation of reactive oxygen species metabolic process
BP	IMP	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway
CC	IDA	GO:0000790	nuclear chromatin
CC	IDA	GO:0005622	intracellular
CC	IDA	GO:0005634	nucleus
CC	IMP	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005669	transcription factor TFIID complex
CC	IDA	GO:0005730	nucleolus
CC	IDA	GO:0005737	cytoplasm
CC	IMP	GO:0005737	cytoplasm
CC	IDA	GO:0005739	mitochondrion
CC	IEA	GO:0005759	mitochondrial matrix
CC	IEA	GO:0005783	endoplasmic reticulum
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0016363	nuclear matrix
CC	IDA	GO:0016604	nuclear body
CC	IDA	GO:0016605	PML body
CC	IDA	GO:0032991	protein-containing complex
CC	IMP	GO:0032991	protein-containing complex
MF	IDA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	ISS	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
MF	IDA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IDA	GO:0000990	transcription factor activity, core RNA polymerase binding
MF	IDA	GO:0001046	core promoter sequence-specific DNA binding
MF	IDA	GO:0001074	transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly
MF	IPI	GO:0001085	RNA polymerase II transcription factor binding
MF	IPI	GO:0001094	TFIID-class transcription factor binding
MF	IDA	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MF	IPI	GO:0002020	protease binding
MF	IPI	GO:0002039	p53 binding
MF	IDA	GO:0003677	DNA binding
MF	IMP	GO:0003677	DNA binding
MF	IDA	GO:0003682	chromatin binding
MF	IDA	GO:0003700	DNA-binding transcription factor activity
MF	IMP	GO:0003700	DNA-binding transcription factor activity
MF	IDA	GO:0003730	mRNA 3'-UTR binding
MF	IDA	GO:0005507	copper ion binding
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005524	ATP binding
MF	IPI	GO:0008134	transcription factor binding
MF	TAS	GO:0008270	zinc ion binding
MF	IPI	GO:0019899	enzyme binding
MF	IPI	GO:0019901	protein kinase binding
MF	IPI	GO:0019903	protein phosphatase binding
MF	IPI	GO:0030971	receptor tyrosine kinase binding
MF	IPI	GO:0031625	ubiquitin protein ligase binding
MF	IPI	GO:0035035	histone acetyltransferase binding
MF	IMP	GO:0042802	identical protein binding
MF	IPI	GO:0042802	identical protein binding
MF	IPI	GO:0042826	histone deacetylase binding
MF	IPI	GO:0043621	protein self-association
MF	IDA	GO:0044212	transcription regulatory region DNA binding
MF	IPI	GO:0046982	protein heterodimerization activity
MF	IPI	GO:0047485	protein N-terminus binding
MF	IPI	GO:0051087	chaperone binding
MF	IPI	GO:0051721	protein phosphatase 2A binding
MF	IPI	GO:0097718	disordered domain specific binding
MF	IDA	GO:1990841	promoter-specific chromatin binding

Gene expression in normal tissue: TP53

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TP53

Database	Pathway ID	Pathway Des.
pharmgkb	PA165291507	Fluoropyrimidine Pathway, Pharmacodynamics
pharmgkb	PA165292163	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
pid	ap1_pathway	AP-1 transcription factor network
pid	aurora_a_pathway	Aurora A signaling
pid	bard1pathway	BARD1 signaling events
pid	hdac_classiii_pathway	Signaling events mediated by HDAC Class III
pid	hif1apathway	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
pid	lkb1_pathway	LKB1 signaling events
pid	myc_activpathway	Validated targets of C-MYC transcriptional activation
pid	p38alphabetadownstreampathway	Signaling mediated by p38-alpha and p38-beta
pid	p53downstreampathway	Direct p53 effectors
pid	p53regulationpathway	p53 pathway
pid	p75ntrpathway	p75(NTR)-mediated signaling
pid	plk3_pathway	PLK3 signaling events
pid	reg_gr_pathway	Glucocorticoid receptor regulatory network
wikipathways	WP1403	AMP-activated Protein Kinase (AMPK) Signaling
wikipathways	WP1530	miRNA Regulation of DNA Damage Response
wikipathways	WP1545	miRNAs involved in DNA damage response
wikipathways	WP1601	Fluoropyrimidine Activity
wikipathways	WP1742	TP53 Network
wikipathways	WP176	Folate Metabolism
wikipathways	WP1772	Apoptosis Modulation and Signaling
wikipathways	WP179	Cell Cycle
wikipathways	WP2059	Alzheimers Disease
wikipathways	WP2249	Metastatic brain tumor
wikipathways	WP2261	Signaling Pathways in Glioblastoma
wikipathways	WP2363	Gastric Cancer Network 2
wikipathways	WP2374	Oncostatin M Signaling Pathway
wikipathways	WP2431	Spinal Cord Injury
wikipathways	WP2446	Retinoblastoma (RB) in Cancer
wikipathways	WP2447	Amyotrophic lateral sclerosis (ALS)
wikipathways	WP2516	ATM Signaling Pathway
wikipathways	WP254	Apoptosis
wikipathways	WP2815	Mammary gland development pathway - Involution (Stage 4 of 4)
wikipathways	WP2828	Bladder Cancer
wikipathways	WP3286	Copper homeostasis
wikipathways	WP3303	Rac1-Pak1-p38-MMP-2 pathway
wikipathways	WP3611	Photodynamic therapy-induced AP-1 survival signaling.
wikipathways	WP3614	Photodynamic therapy-induced HIF-1 survival signaling
wikipathways	WP3639	Apoptotic Signaling Pathway
wikipathways	WP3646	Hepatitis C and Hepatocellular Carcinoma
wikipathways	WP3651	Pathways Affected in Adenoid Cystic Carcinoma
wikipathways	WP366	TGF-beta Signaling Pathway
wikipathways	WP3672	LncRNA-mediated mechanisms of therapeutic resistance
wikipathways	WP3807	Regulation of TP53 Expression and Degradation
wikipathways	WP382	MAPK Signaling Pathway
wikipathways	WP3981	miRNA regulation of prostate cancer signaling pathways
wikipathways	WP3982	miRNA regulation of p53 pathway in prostate cancer
wikipathways	WP399	Wnt Signaling Pathway and Pluripotency
wikipathways	WP4066	Interleukin-4 and 13 signaling
wikipathways	WP4155	Endometrial cancer
wikipathways	WP4172	PI3K-Akt Signaling Pathway
wikipathways	WP4191	Caloric restriction and aging
wikipathways	WP4206	Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway
wikipathways	WP4216	Chromosomal and microsatellite instability in colorectal cancer
wikipathways	WP4239	EMT transition in Colorectal Cancer
wikipathways	WP45	G1 to S cell cycle control
wikipathways	WP615	Senescence and Autophagy in Cancer
wikipathways	WP673	ErbB Signaling Pathway
wikipathways	WP707	DNA Damage Response
wikipathways	WP710	DNA Damage Response (only ATM dependent)
smpdb	SMP00436	Vinblastine Action Pathway
smpdb	SMP00437	Vincristine Action Pathway
smpdb	SMP00438	Vindesine Action Pathway
smpdb	SMP00439	Vinorelbine Action Pathway
netpath	Pathway_EGFR1	EGFR1
netpath	Pathway_Oncostatin_M	Oncostatin_M
netpath	Pathway_TGF_beta_Receptor	TGF_beta_Receptor
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04071	Sphingolipid signaling pathway - Homo sapiens (human)
kegg	hsa04110	Cell cycle - Homo sapiens (human)
kegg	hsa04115	p53 signaling pathway - Homo sapiens (human)
kegg	hsa04137	Mitophagy - animal - Homo sapiens (human)
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa04210	Apoptosis - Homo sapiens (human)
kegg	hsa04211	Longevity regulating pathway - Homo sapiens (human)
kegg	hsa04216	Ferroptosis - Homo sapiens (human)
kegg	hsa04218	Cellular senescence - Homo sapiens (human)
kegg	hsa04310	Wnt signaling pathway - Homo sapiens (human)
kegg	hsa04722	Neurotrophin signaling pathway - Homo sapiens (human)
kegg	hsa04919	Thyroid hormone signaling pathway - Homo sapiens (human)
kegg	hsa05014	Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegg	hsa05016	Huntington,s disease - Homo sapiens (human)
kegg	hsa05160	Hepatitis C - Homo sapiens (human)
kegg	hsa05161	Hepatitis B - Homo sapiens (human)
kegg	hsa05162	Measles - Homo sapiens (human)
kegg	hsa05165	Human papillomavirus infection - Homo sapiens (human)
kegg	hsa05166	HTLV-I infection - Homo sapiens (human)
kegg	hsa05167	Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegg	hsa05168	Herpes simplex infection - Homo sapiens (human)
kegg	hsa05169	Epstein-Barr virus infection - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05202	Transcriptional misregulation in cancer - Homo sapiens (human)
kegg	hsa05203	Viral carcinogenesis - Homo sapiens (human)
kegg	hsa05205	Proteoglycans in cancer - Homo sapiens (human)
kegg	hsa05206	MicroRNAs in cancer - Homo sapiens (human)
kegg	hsa05210	Colorectal cancer - Homo sapiens (human)
kegg	hsa05212	Pancreatic cancer - Homo sapiens (human)
kegg	hsa05213	Endometrial cancer - Homo sapiens (human)
kegg	hsa05214	Glioma - Homo sapiens (human)
kegg	hsa05215	Prostate cancer - Homo sapiens (human)
kegg	hsa05216	Thyroid cancer - Homo sapiens (human)
kegg	hsa05217	Basal cell carcinoma - Homo sapiens (human)
kegg	hsa05218	Melanoma - Homo sapiens (human)
kegg	hsa05219	Bladder cancer - Homo sapiens (human)
kegg	hsa05220	Chronic myeloid leukemia - Homo sapiens (human)
kegg	hsa05222	Small cell lung cancer - Homo sapiens (human)
kegg	hsa05223	Non-small cell lung cancer - Homo sapiens (human)
kegg	hsa05224	Breast cancer - Homo sapiens (human)
kegg	hsa05225	Hepatocellular carcinoma - Homo sapiens (human)
kegg	hsa05226	Gastric cancer - Homo sapiens (human)
kegg	hsa05230	Central carbon metabolism in cancer - Homo sapiens (human)
kegg	hsa05418	Fluid shear stress and atherosclerosis - Homo sapiens (human)
reactome	R-HSA-109581	Apoptosis
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-109606	Intrinsic Pathway for Apoptosis
reactome	R-HSA-111448	Activation of NOXA and translocation to mitochondria
reactome	R-HSA-114452	Activation of BH3-only proteins
reactome	R-HSA-1257604	PIP3 activates AKT signaling
reactome	R-HSA-1257604	PIP3 activates AKT signaling
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-139915	Activation of PUMA and translocation to mitochondria
reactome	R-HSA-157118	Signaling by NOTCH
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-168256	Immune System
reactome	R-HSA-1912408	Pre-NOTCH Transcription and Translation
reactome	R-HSA-1912422	Pre-NOTCH Expression and Processing
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-2559580	Oxidative Stress Induced Senescence
reactome	R-HSA-2559583	Cellular Senescence
reactome	R-HSA-2559584	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
reactome	R-HSA-2559585	Oncogene Induced Senescence
reactome	R-HSA-2559586	DNA Damage/Telomere Stress Induced Senescence
reactome	R-HSA-2990846	SUMOylation
reactome	R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins
reactome	R-HSA-3232118	SUMOylation of transcription factors
reactome	R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-390466	Chaperonin-mediated protein folding
reactome	R-HSA-390471	Association of TriC/CCT with target proteins during biosynthesis
reactome	R-HSA-391251	Protein folding
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-453274	Mitotic G2-G2/M phases
reactome	R-HSA-5357801	Programmed Cell Death
reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
reactome	R-HSA-5633007	Regulation of TP53 Activity
reactome	R-HSA-5633008	TP53 Regulates Transcription of Cell Death Genes
reactome	R-HSA-5688426	Deubiquitination
reactome	R-HSA-5689880	Ub-specific processing proteases
reactome	R-HSA-5689896	Ovarian tumor domain proteases
reactome	R-HSA-5693532	DNA Double-Strand Break Repair
reactome	R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
reactome	R-HSA-5693606	DNA Double Strand Break Response
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling
reactome	R-HSA-6791312	TP53 Regulates Transcription of Cell Cycle Genes
reactome	R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes
reactome	R-HSA-6803204	TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
reactome	R-HSA-6803205	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
reactome	R-HSA-6803207	TP53 Regulates Transcription of Caspase Activators and Caspases
reactome	R-HSA-6803211	TP53 Regulates Transcription of Death Receptors and Ligands
reactome	R-HSA-6804114	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
reactome	R-HSA-6804115	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
reactome	R-HSA-6804116	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
reactome	R-HSA-6804754	Regulation of TP53 Expression
reactome	R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation
reactome	R-HSA-6804757	Regulation of TP53 Degradation
reactome	R-HSA-6804758	Regulation of TP53 Activity through Acetylation
reactome	R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors
reactome	R-HSA-6804760	Regulation of TP53 Activity through Methylation
reactome	R-HSA-6806003	Regulation of TP53 Expression and Degradation
reactome	R-HSA-6807070	PTEN Regulation
reactome	R-HSA-6807070	PTEN Regulation
reactome	R-HSA-6811555	PI5P Regulates TP53 Acetylation
reactome	R-HSA-69275	G2/M Transition
reactome	R-HSA-69278	Cell Cycle, Mitotic
reactome	R-HSA-69473	G2/M DNA damage checkpoint
reactome	R-HSA-69481	G2/M Checkpoints
reactome	R-HSA-69541	Stabilization of p53
reactome	R-HSA-69560	Transcriptional activation of p53 responsive genes
reactome	R-HSA-69563	p53-Dependent G1 DNA Damage Response
reactome	R-HSA-69580	p53-Dependent G1/S DNA damage checkpoint
reactome	R-HSA-69615	G1/S DNA Damage Checkpoints
reactome	R-HSA-69620	Cell Cycle Checkpoints
reactome	R-HSA-69895	Transcriptional activation of cell cycle inhibitor p21
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-73894	DNA Repair
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint
reactome	R-HSA-8878159	Transcriptional regulation by RUNX3
reactome	R-HSA-8941855	RUNX3 regulates CDKN1A transcription
reactome	R-HSA-8943724	Regulation of PTEN gene transcription
reactome	R-HSA-8943724	Regulation of PTEN gene transcription
reactome	R-HSA-8953897	Cellular responses to external stimuli
reactome	R-HSA-9006925	Intracellular signaling by second messengers
reactome	R-HSA-9006925	Intracellular signaling by second messengers
reactome	R-HSA-983231	Factors involved in megakaryocyte development and platelet production
biocarta	arfpathway	tumor suppressor arf inhibits ribosomal biogenesis
biocarta	atmpathway	atm signaling pathway
biocarta	atrbrcapathway	role of brca1 brca2 and atr in cancer susceptibility
biocarta	btg2pathway	btg family proteins and cell cycle regulation
biocarta	chemicalpathway	apoptotic signaling in response to dna damage
biocarta	efppathway	estrogen responsive protein efp controls cell cycle and breast tumors growth
biocarta	g1pathway	cell cycle: g1/s check point
biocarta	g2pathway	cell cycle: g2/m checkpoint
biocarta	p53hypoxiapathway	hypoxia and p53 in the cardiovascular system
biocarta	p53pathway	p53 signaling pathway
biocarta	plk3pathway	regulation of cell cycle progression by plk3
biocarta	pmlpathway	regulation of transcriptional activity by pml
biocarta	rbpathway	rb tumor suppressor/checkpoint signaling in response to dna damage
biocarta	rnapathway	double stranded rna induced gene expression
biocarta	telpathway	telomeres telomerase cellular aging and immortality
biocarta	tertpathway	overview of telomerase protein component gene htert transcriptional regulation
biocarta	tidpathway	chaperones modulate interferon signaling pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD147	Prima-1	1
iGMDRD552	AZD-1775	3
iGMDRD264	Bryostatin 1	1
iGMDRD322	FK 866	4
iGMDRD367	Ro 28-1675	1
iGMDRD993	QL-XII-61	1
iGMDRD662	JQ-1	2
iGMDRD455	Idelalisib	1
iGMDRD215	CCT007093	1
iGMDRD311	Dacinostat	1
iGMDRD213	SMR000068650	1
iGMDRD77	Itraconazole	1
iGMDRD103	SN-38	3
iGMDRD121	GMX1778	2
iGMDRD158	NSC141540	6
iGMDRD293	Bleomycin	3
iGMDRD137	Indisulam	8
iGMDRD5	Tyrphostin AG 1478	2
iGMDRD879	chemotherapy	2
iGMDRD1002	rTRAIL	2
iGMDRD883	CIL55A	1
iGMDRD154	NSC23766	2
iGMDRD775	NCGC00346967-01	1
iGMDRD314	Tanespimycin	2
iGMDRD352	PD-0325901	1
iGMDRD237	ABT-751	2
iGMDRD560	MK-2206	1
iGMDRD110	ETOMOXIR	1
iGMDRD50	Cytarabine	1
iGMDRD276	AS 605240	1
iGMDRD79	Gemcitabine	10
iGMDRD475	BX 912	1
iGMDRD719	IOX2	1
iGMDRD992	QL-VIII-58	1
iGMDRD356	PNU-74654	1
iGMDRD23	Gossypol	1
iGMDRD602	Foretinib	1
iGMDRD133	Lapatinib	1
iGMDRD730	Kahalalide F	1
iGMDRD146	Elesclomol	1
iGMDRD468	AZ628	1
iGMDRD187	BRD9876	1
iGMDRD920	HSP90 inhibitor	4
iGMDRD568	SCHEMBL15005512	1
iGMDRD458	GSK-319347A	1
iGMDRD493	GSK269962A	4
iGMDRD259	EX-527	1
iGMDRD470	Trametinib	1
iGMDRD778	SCHEMBL13586708	1
iGMDRD1032	VNLG/124	1
iGMDRD363	OSI-930	1
iGMDRD793	BEC (hydrochloride)	3
iGMDRD21	Fluorouracil	2
iGMDRD61	Kinetin riboside	4
iGMDRD748	PHA-665752	2
iGMDRD546	BMS-754807	7
iGMDRD670	ML 210	4
iGMDRD403	BAY 61-3606	3
iGMDRD397	Pazopanib	1
iGMDRD409	Saracatinib	1
iGMDRD433	Lexibulin	1
iGMDRD654	SL 0101-1	1
iGMDRD749	ZINC6718453	1
iGMDRD425	ERASTIN	4
iGMDRD886	Compound 1541A	3
iGMDRD179	Shikonin	2
iGMDRD876	CDK4/CDK6 inhibitor (abemaciclib)	1
iGMDRD246	NPC26	4
iGMDRD695	FR-180204	2
iGMDRD384	EHT-1864	1
iGMDRD42	Vorinostat	1
iGMDRD882	CIL41	3
iGMDRD650	Abemaciclib	1
iGMDRD3	PD-173074	2
iGMDRD755	XMD13-2	2
iGMDRD544	Vismodegib (GDC-0449)	1
iGMDRD88	AICA ribonucleotide	1
iGMDRD434	BMS-536924	3
iGMDRD192	CIL56	2
iGMDRD808	Alemtuzumab	1
iGMDRD267	Oligomycin A	2
iGMDRD785	XMD15-27	1
iGMDRD1016	THZ-2-49	1
iGMDRD310	Everolimus	3
iGMDRD211	(1S,3R)-RSL3	2
iGMDRD177	Teniposide	1
iGMDRD450	JNJ-26854165	1
iGMDRD435	BI-2536	1
iGMDRD132	(-)-gallocatechin-3-O-gallate	4
iGMDRD85	Ursolic acid	4
iGMDRD536	PLX-4720	1
iGMDRD116	CD437	2
iGMDRD125	BIRB-796	2
iGMDRD160	Cis-Platin	5
iGMDRD424	Tamatinib	1
iGMDRD652	UNC0638	1
iGMDRD307	Manumycin A	2
iGMDRD512	nutlin 3	1
iGMDRD792	Cetuximab	2
iGMDRD291	AC1NS4S0	1
iGMDRD454	JNK Inhibitor VIII	1
iGMDRD453	GW2580	2
iGMDRD887	Compound 23 citrate	3
iGMDRD432	AT-7519	2
iGMDRD440	Nutlin-3A	21
iGMDRD309	17AAG	1
iGMDRD390	MDM2 inhibitor	2
iGMDRD320	PIK-93	2
iGMDRD33	Entinostat	1
iGMDRD134	Sorafenib	2
iGMDRD378	ZM-447439	1
iGMDRD280	CYTOCHALASIN B	1
iGMDRD375	GW-405833	2
iGMDRD218	XAV 939	1
iGMDRD776	QL-XI-92	2
iGMDRD446	LY 2183240	1
iGMDRD281	Vinorelbine base	1
iGMDRD253	Vincaleukoblastine	1
iGMDRD498	GW441756X	1
iGMDRD718	Pyrvinium pamoate	4
iGMDRD66	Doxorubicin	7
iGMDRD144	NSC95397	2
iGMDRD494	Neopeltolide	1
iGMDRD129	SB-216763	1
iGMDRD361	5Z-7-Oxozeaenol	1
iGMDRD599	Salermide	6
iGMDRD579	PF750	1
iGMDRD286	Nsc 632839	1
iGMDRD366	PI-103	4
iGMDRD705	Nakiterpiosin	1
iGMDRD660	GSK-1070916	2
iGMDRD289	Parthenolide	2
iGMDRD105	Triptolide	1
iGMDRD288	Carboplatin	1
iGMDRD667	BIX02189	1
iGMDRD496	Pramlintide [USAN]	3
iGMDRD402	AKT Inhibitor VIII	2
iGMDRD467	Motesanib	1
iGMDRD722	AZD6738	4
iGMDRD176	Decitabine	4
iGMDRD49	Mitomycin	7
iGMDRD341	Triacsin c	4
iGMDRD541	SNX-2112 (PF-04928473)	1
iGMDRD150	RITA	4
iGMDRD532	Olaparib	3
iGMDRD594	AZD-8055	1
iGMDRD523	Cyanoquinoline, 11	1
iGMDRD564	GSK-650394	1
iGMDRD48	Dexamethasone	2
iGMDRD248	BRD4354	1
iGMDRD190	Nilotinib	1
iGMDRD524	ISX-9	3
iGMDRD188	Piperlongumine	2
iGMDRD399	Selumetinib	4
iGMDRD391	OSU-03012	1
iGMDRD284	Palbociclib	1
iGMDRD429	Amuvatinib	2
iGMDRD117	Docetaxel	2
iGMDRD1019	TL-2-105	1
iGMDRD801	2,4-dideoxy-DC-45-A2	2
iGMDRD44	Temozolomide	1
iGMDRD593	CX-5461	1
iGMDRD52	Rotenone	2
iGMDRD474	Avrainvillamide	2
iGMDRD394	BX-795	1
iGMDRD687	I-BET151	1
iGMDRD107	Valdecoxib	1
iGMDRD316	N9-Isopropyl-olomoucine	1
iGMDRD2	PK-11195	2
iGMDRD152	179324-69-7	1
iGMDRD1033	WEE1 inhibitor	3
iGMDRD283	Bosutinib	1
iGMDRD135	Lenalidomide	1
iGMDRD781	Sirolimus	2
iGMDRD126	Tipifarnib	2
iGMDRD151	CHM-1	2
iGMDRD571	Cabozantinib	1
iGMDRD443	Linifanib	1
iGMDRD420	Leucascandrolide A	2
iGMDRD937	KIN001-236	1
iGMDRD300	Tozasertib	3
iGMDRD505	Pevonedistat	1
iGMDRD935	JQ12	1
iGMDRD646	PHA-793887	2
iGMDRD172	T091317	1
iGMDRD389	SB525334	1
iGMDRD459	RO-3306	2
iGMDRD504	Obatoclax	1
iGMDRD68	Paclitaxel	2
iGMDRD374	Zibotentan (ZD4054)	1
iGMDRD292	NSC87877	1
iGMDRD368	Oxaliplatin	1
iGMDRD456	Crizotinib	2
iGMDRD614	Dabrafenib	2
iGMDRD345	Compound 10b [PMID: 11504634]	3
iGMDRD701	NVP-AUY922	1
iGMDRD497	16beta-Bromoandrosterone	1
iGMDRD382	CEP-701	2
iGMDRD262	KU-55933	1
iGMDRD360	SB-505124	1
iGMDRD347	Y-39983	6
iGMDRD690	PRIMA-1MET	1
iGMDRD131	Erlotinib	1
iGMDRD332	A-770041	1
iGMDRD577	BIX01294	5
iGMDRD398	Sepantronium	1
iGMDRD562	Navitoclax	2
iGMDRD573	GSK-1904529A	2
iGMDRD758	JW-7-24-1	1
iGMDRD782	DC-45-A2	4
iGMDRD388	YM201636	1
iGMDRD759	PFI-1	3
iGMDRD478	ABT-888	1
iGMDRD870	BRD63610	1
iGMDRD574	Ruxolitinib	1
iGMDRD669	PDK1 inhibitor	2
iGMDRD509	NVP-BHG712	2
iGMDRD491	TAE-684	1
iGMDRD255	SB225002	2
iGMDRD109	Gefitinib	1
iGMDRD401	Afatinib	1
iGMDRD673	LSM-1215	1
iGMDRD83	Capecitabine	1
iGMDRD805	Adjuvant Chemotherapy	2
iGMDRD189	CGP 60474	1
iGMDRD608	Refametinib	1
iGMDRD163	all trans Retinoic Acid	1
iGMDRD112	Methotrexate	1
iGMDRD136	Nutlin-3	1
iGMDRD387	CHIR-99021	3
iGMDRD1008	SR-II-138A	4
iGMDRD659	Avagacestat (BMS-708163)	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TP53

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.