iGMDRD698


Canonical SMILES: CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C

InChI: InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)

InChI Key: JWNPDZNEKVCWMY-UHFFFAOYSA-N

Standard NamePubchem CIDDrug StatusDrug Type
Neratinib53398700AloneSmall Molecule

Drug Targets:

EGFRERBB2

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
64901RANBP175
1105CHD11
7074TIAM14
23085ERC11
7128TNFAIP32
21ABCA34
5933RBL13
2986GUCY2F2
79947DHDDS1
57554LRRC72
7272TTK2
8289ARID1A4
3939LDHA6
9475ROCK25
6597SMARCA42
9869SETDB12
7764ZNF2175
11116FGFR1OP2
56776FMN22
3320HSP90AA11
3066HDAC23
22853LMTK23
7253TSHR3
23310NCAPD33
140469MYO3B2
54822TRPM76
1387CREBBP2
23225NUP2103
2313FLI13
10178TENM12
9048ARTN5
7373COL14A11
5314PKHD16
139378ADGRG43
145264SERPINA123
9578CDC42BPB2
641BLM3
4595MUTYH4
4610MYCL3
84033OBSCN2
25937WWTR11
7025NR2F11
8313AXIN24
2042EPHA31
2736GLI23
55681SCYL22
2045EPHA74
23405DICER16
2064ERBB247
6850SYK1
7486WRN3
2068ERCC22
8859STK196
157285PRAG11
8515ITGA102
472ATM1
1496CTNNA23
7010TEK2
5450POU2AF11
23152CIC3
2066ERBB43
10413YAP13
6092ROBO23
6794STK119
25836NIPBL1
3791KDR4
2263FGFR22
1019CDK41
9967THRAP32
5604MAP2K16
1555CYP2B61
55034MOCOS3
136332LRGUK3
5871MAP4K23
4089SMAD41
1616DAXX4
3417IDH14
2047EPHB11
7786MAP3K123
57144PAK53
3702ITK5
3239HOXD136
5290PIK3CA4
253260RICTOR2
2318FLNC1
10565ARFGEF15
64919BCL11B5
1956EGFR1
157680VPS13B3
3065HDAC13
64750SMURF25
2624GATA26
1459CSNK2A26
8013NR4A33
26278SACS2
673BRAF4
84630TTBK12
84879MFSD2A3
3315HSPB13
23532PRAME1
8924HERC23
89795NAV38
65268WNK21
6095RORA5
57507ZNF6082
8029CUBN3
8626TP631
9064MAP3K66
7849PAX84
9451EIF2AK32
4791NFKB26
23742NPAP13
57521RPTOR3
140609NEK73
4914NTRK13
8522GAS72
5582PRKCG4
6789STK43
7454WAS3
2046EPHA83
10595ERN22
344905ATP13A52
7094TLN13
4628MYH106
598BCL2L11
57448BIRC63
3717JAK23
23139MAST26
2157F82
7227TRPS19
3709ITPR21
6778STAT63
84072HORMAD13
7046TGFBR13
51167CYB5R46
2074ERCC65
8661EIF3A3
3691ITGB43
1234CCR52
4205MEF2A3
7040TGFB13
51135IRAK41
11086ADAM293
23072HECW15
1840DTX13
5288PIK3C2G2
2044EPHA55
4629MYH116
30811HUNK6
2892GRIA32
4486MST1R3

Gene in drug-gene network: Network Plot

Models in Neratinib

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