iGMDRD532


Canonical SMILES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

InChI: InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)

InChI Key: FDLYAMZZIXQODN-UHFFFAOYSA-N

Standard NameCHEMBLPubchem CIDDrug StatusDrug Type
OlaparibCHEMBL521686 23725600AloneSmall Molecule

Drug Targets:

PARP1PARP2

Drug Pathways:

Genome integrity

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
331XIAP3
10221TRIB13
10987COPS51
132ADK3
4627MYH92
23513SCRIB3
2956MSH61
51765STK263
23624CBLC1
1520CTSS1
9706ULK23
3845KRAS1
4750NEK13
3939LDHA2
3551IKBKB3
10395DLC12
3069HDLBP3
6657SOX23
390502SERPINA24
5079PAX53
4170MCL11
3066HDAC21
9757KMT2B1
114908TMEM1233
1387CREBBP4
2043EPHA43
5788PTPRC2
10013HDAC62
11200CHEK23
10178TENM12
51755CDK121
5596MAPK43
57472CNOT63
5966REL3
5159PDGFRB1
55300PI4K2B3
2033EP3001
54567DLL42
4361MRE111
10746MAP3K23
440279UNC13C3
9693RAPGEF21
32ACACB2
329BIRC23
22806IKZF33
114548NLRP32
4739NEDD93
238ALK1
57476GRAMD1B2
65217PCDH152
8395PIP5K1B2
23191CYFIP13
783CACNB23
9759HDAC42
1452CSNK1A12
6709SPTAN12
1973EIF4A13
6098ROS13
6917TCEA13
472ATM10
5924RASGRF22
1496CTNNA21
839CASP63
1029CDKN2A1
157753TMEM744
1910EDNRB3
28514DLL13
3932LCK3
7157TP533
57194ATP10A2
836CASP33
2263FGFR21
105ADARB23
863CBFA2T33
23043TNIK1
7422VEGFA1
55437STRADB3
2177FANCD23
4436MSH23
50945TBX222
652BMP43
6035RNASE13
5650KLK72
8997KALRN3
4437MSH35
23269MGA1
3643INSR3
2175FANCA2
54658UGT1A11
672BRCA118
546ATRX2
6134RPL103
10926DBF42
8216LZTR11
5290PIK3CA1
3720JARID23
1687GSDME2
5366PMAIP13
675BRCA218
1956EGFR2
4609MYC2
64750SMURF22
90956ADCK23
6885MAP3K73
93627TBCK2
10186LHFPL62
673BRAF4
1213CLTC2
5781PTPN111
23532PRAME3
65268WNK22
6095RORA2
146057TTBK23
7301TYRO31
11262SP1403
4853NOTCH23
9509ADAMTS21
3229HOXC133
10010TANK4
5728PTEN5
7030TFE33
22883CLSTN13
667DST1
8301PICALM3
171023ASXL12
55356SLC22A153
23389MED13L2
55359STYK13
55561CDC42BPG3
221895JAZF13
22843PPM1E1
29994BAZ2B1
51151SLC45A23
10735STAG21
55289ACOXL3
54101RIPK43
6093ROCK13
2130EWSR12
131890GRK73
1719DHFR5
57007ACKR33
80216ALPK15
5925RB12
4893NRAS1
2065ERBB31
7403KDM6A1
54790TET23
8717TRADD3
2308FOXO13
2258FGF133
4302MLLT63
51364ZMYND103
197259MLKL2
4299AFF12
865CBFB3
2073ERCC52
595CCND11
4763NF13
1612DAPK12
10891PPARGC1A3
6868ADAM173

Gene in drug-gene network: Network Plot

Models in Olaparib

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