iGMDRD202


Canonical SMILES: COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

InChI: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChI Key: VFLDPWHFBUODDF-FCXRPNKRSA-N

Standard NameCHEMBLPubchem CIDDRUGBANK IDDrug StatusDrug Type
CurcuminCHEMBL140 969516DB11672AloneSmall Molecule

Drug Class:

AlkanesAnalgesicsAnalgesics, Non-NarcoticAnti-Inflammatory AgentsAntineoplastic AgentsAntirheumatic AgentsBenzene DerivativesCatecholsCentral Nervous System AgentsColoring AgentsCombined Inhibitors of CYP3A4 and P-glycoproteinCombined Inhibitors of CYP3A4 and P-glycoprotein (Strong)Cytochrome P-450 CYP1A2 InhibitorsCytochrome P-450 CYP1A2 Inhibitors (moderate)Cytochrome P-450 CYP2B6 InhibitorsCytochrome P-450 CYP2B6 Inhibitors (moderate)Cytochrome P-450 CYP2C9 InhibitorsCytochrome P-450 CYP2C9 Inhibitors (strong)Cytochrome P-450 CYP2D6 InhibitorsCytochrome P-450 CYP2D6 Inhibitors (moderate)Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A Inhibitors (strong)Cytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (strong)Cytochrome P-450 Enzyme InhibitorsDiarylheptanoidsEnzyme InhibitorsHeptanesHydrocarbonsHydrocarbons, AcyclicHydrocarbons, AromaticHydrocarbons, CyclicP-glycoprotein/ABCB1 InhibitorsP-glycoprotein/ABCB1 SubstratesPeripheral Nervous System AgentsPhenolsSensory System AgentsSpecialty Uses of Chemicals


Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
331XIAP5
64901RANBP174
1147CHUK4
7514XPO11
8999CDKL21
7074TIAM13
79054TRPM83
7128TNFAIP32
5933RBL12
26191PTPN223
2200FBN12
1520CTSS3
1969EPHA24
7272TTK3
3845KRAS2
23097CDK194
8289ARID1A3
80070ADAMTS203
8266UBL4A1
3939LDHA3
79092CARD143
2475MTOR1
9475ROCK22
83942TSSK1B2
4036LRP23
7764ZNF2175
10395DLC13
3069HDLBP3
83481EPPK11
390502SERPINA24
56776FMN23
10892MALT11
1607DGKB2
3694ITGB66
22853LMTK23
7253TSHR5
7098TLR31
10645CAMKK24
8749ADAM185
55534MAML33
8737RIPK13
9816URB23
7048TGFBR24
54822TRPM76
51199NIN3
1813DRD26
1387CREBBP3
8106PABPN13
2043EPHA42
5788PTPRC3
2313FLI13
56164STK315
31ACACA5
10178TENM11
51755CDK122
79858NEK114
9048ARTN6
8295TRRAP5
10438C1D5
27148STK363
2120ETV62
5314PKHD16
139378ADGRG43
89910UBE3B1
55294FBXW72
8030CCDC66
9578CDC42BPB4
10746MAP3K23
23522KAT6B3
57670KIAA15492
22861NLRP14
440279UNC13C7
256646NUTM12
2051EPHB63
9693RAPGEF21
3556IL1RAP4
329BIRC23
4300MLLT32
8396PIP4K2B4
6041RNASEL3
80351TNKS24
8313AXIN23
2042EPHA32
51343FZR13
730249ACOD16
80129CCDC1705
10188TNK24
9636ISG156
2908NR3C14
83990BRIP11
51804SIX42
4739NEDD93
55681SCYL23
2045EPHA73
23405DICER12
171019ADAMTS193
287015TRIM426
57476GRAMD1B1
26750RPS6KC13
7486WRN2
1456CSNK1G32
783CACNB24
5580PRKCD3
6416MAP2K41
1452CSNK1A12
8714ABCC33
6709SPTAN16
8215DVL1P13
1909EDNRA2
50488MINK12
5591PRKDC3
8859STK191
6098ROS13
3685ITGAV2
80243PREX21
2580GAK6
28996HIPK21
53942CNTN55
4087SMAD24
6792CDKL53
1496CTNNA22
7010TEK5
5450POU2AF16
5327PLAT5
7184HSP90B14
1910EDNRB3
3236HOXD102
5834PYGB1
58508KMT2C2
2099ESR14
6092ROBO26
7704ZBTB163
4088SMAD33
4855NOTCH42
6794STK115
2322FLT36
54498SMOX6
130399ACVR1C3
1019CDK41
11213IRAK33
1045CDX21
5604MAP2K13
4869NPM12
863CBFA2T33
8874ARHGEF73
1555CYP2B64
55034MOCOS2
23043TNIK3
4921DDR24
5077PAX32
57188ADAMTSL31
3187HNRNPH11
65125WNK17
136332LRGUK2
4436MSH22
50945TBX223
676BRDT3
7175TPR3
80205CHD91
10499NCOA26
8997KALRN3
3643INSR3
57111RAB251
57551TAOK12
23469PHF32
672BRCA11
2060EPS153
7204TRIO1
9448MAP4K43
546ATRX5
3417IDH12
5297PI4KA1
10769PLK23
30827CXXC11
8216LZTR11
3702ITK4
3239HOXD133
1687GSDME5
8202NCOA33
5045FURIN3
10565ARFGEF11
64919BCL11B3
4803NGF3
7075TIE12
640BLK1
841CASP83
11064CNTRL9
64750SMURF25
1459CSNK2A26
26278SACS6
894CCND23
29951PDZRN43
51265CDKL33
3553IL1B6
5592PRKG14
1594CYP27B16
5747PTK26
5156PDGFRA2
91754NEK92
84630TTBK13
1213CLTC4
3315HSPB16
23532PRAME1
780DDR14
57538ALPK33
8924HERC22
65268WNK23
867CBL3
6095RORA3
8029CUBN9
5128CDK173
8626TP632
9113LATS12
460ASTN12
7849PAX86
5979RET3
9321TRIP111
9451EIF2AK32
654780LOC6547806
8491MAP4K33
55521TRIM363
10752CHL16
57521RPTOR3
5595MAPK32
1869E2F16
22883CLSTN12
667DST4
3554IL1R19
23542MAPK8IP23
2324FLT46
658BMPR1B1
5896RAG13
3899AFF31
8522GAS74
5582PRKCG8
7059THBS33
55356SLC22A153
85415RHPN25
203447NRK3
2277VEGFD2
54904NSD31
53904MYO3A6
54861SNRK1
2046EPHA83
128869PIGU3
7150TOP13
8805TRIM242
22843PPM1E1
286151FBXO432
26686OR4E26
344905ATP13A52
51151SLC45A23
5291PIK3CB6
9748SLK6
4774NFIA6
5395PMS22
860RUNX26
53353LRP1B6
1281COL3A16
9201DCLK11
6760SS185
3624INHBA3
5927KDM5A3
3579CXCR23
57007ACKR36
3717JAK22
22982DIP2C2
7099TLR43
7227TRPS12
53335BCL11A3
5506PPP1R3A3
6778STAT62
65267WNK36
6777STAT5B4
5932RBBP81
330BIRC33
182JAG13
51167CYB5R43
5925RB12
4893NRAS3
862RUNX1T13
8661EIF3A9
7403KDM6A1
1234CCR52
2534FYN3
4205MEF2A6
4299AFF13
11086ADAM296
9262STK17B3
55422ZNF3316
4763NF13
8814CDKL12
57697FANCM1
10891PPARGC1A1
2044EPHA53
4593MUSK1
4629MYH116
814CAMK43
3679ITGA72
27255CNTN63
83732RIOK13
2444FRK2
2892GRIA33
5624PROC2

Gene in drug-gene network: Network Plot

Models in Curcumin

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