iGMDRD351


Canonical SMILES: COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=CC=C4C(F)(F)F)OC

InChI: InChI=1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29)

InChI Key: JSKUWFIZUALZLX-UHFFFAOYSA-N

Standard NameCHEMBLPubchem CIDDrug StatusDrug Type
GW843682XCHEMBL514499 9826310AloneSmall Molecule

Drug Targets:

PLK1PLK3

Drug Pathways:

Cell cycle

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
3696ITGB81
64901RANBP172
27102EIF2AK12
1105CHD12
4854NOTCH34
7514XPO12
8999CDKL22
5027P2RX72
10903MTMR113
7837PXDN4
10641NPRL23
8444DYRK33
21ABCA36
132ADK2
5933RBL12
7421VDR1
8915BCL103
6319SCD1
8476CDC42BPA3
7750ZMYM21
4926NUMA14
11183MAP4K56
79947DHDDS4
2956MSH61
2200FBN13
57679ALS25
10783NEK63
4477MSMB2
9706ULK23
51347TAOK31
23097CDK193
6563SLC14A15
2100ESR26
6351CCL43
80070ADAMTS207
701BUB1B6
5934RBL22
2335FN12
4928NUP981
79092CARD142
53616ADAM223
3431SP1106
2161F123
6938TCF123
2475MTOR3
83942TSSK1B4
150209AIFM31
3551IKBKB2
81035COLEC121
3326HSP90AB13
4036LRP22
2176FANCC1
10395DLC11
353345GPR1415
7942TFEB3
56776FMN21
64783RBM156
51684SUFU3
6598SMARCB12
4170MCL13
10142AKAP92
7253TSHR2
23310NCAPD35
5298PI4KB3
2241FER2
6318SERPINB41
1545CYP1B13
7080NKX2-12
51199NIN3
28231SLCO4A12
1387CREBBP2
8106PABPN13
5756TWF18
10454TAB11
2043EPHA43
55023PHIP3
5579PRKCB3
31ACACA3
51755CDK122
79858NEK114
57472CNOT63
10438C1D4
23617TSSK22
5396PRRX12
5159PDGFRB1
7173TPO6
4851NOTCH16
139378ADGRG42
89910UBE3B3
10295BCKDK4
2033EP3003
6927HNF1A5
8784TNFRSF182
4001LMNB16
9578CDC42BPB5
641BLM2
4361MRE113
1454CSNK1E3
3227HOXC113
1453CSNK1D1
6390SDHB6
54477PLEKHA51
57670KIAA15493
440279UNC13C2
4301AFDN1
342667STAC23
342977NANOS31
256646NUTM13
1540CYLD2
1880GPR1834
122011CSNK1A1L1
3927LASP16
6256RXRA4
8852AKAP41
2242FES1
3091HIF1A5
3645INSRR3
8313AXIN23
6091ROBO12
51343FZR11
5330PLCB23
23255MTCL11
730249ACOD13
80129CCDC1703
10188TNK24
10217CTDSPL2
2908NR3C13
83990BRIP14
51804SIX41
5601MAPK93
3688ITGB11
6928HNF1B3
4194MDM42
27324TOX33
284217LAMA12
269AMHR21
207AKT13
23405DICER14
1277COL1A14
85443DCLK34
65266WNK43
6850SYK1
57476GRAMD1B2
65217PCDH156
3916LAMP13
834CASP13
9020MAP3K141
7486WRN3
29775CARD105
440730TRIM673
6416MAP2K41
9759HDAC42
6709SPTAN16
1973EIF4A13
10087COL4A3BP5
50488MINK15
5591PRKDC1
6464SHC13
7166TPH16
8515ITGA102
2778GNAS6
3667IRS11
80243PREX21
472ATM6
1009CDH113
28996HIPK22
575ADGRB12
2734GLG13
84433CARD116
6792CDKL53
54986ULK44
1123CHN16
1496CTNNA23
5450POU2AF14
2066ERBB44
7681MKRN32
5863RGL23
9319TRIP133
2201FBN27
1029CDKN2A2
7184HSP90B12
10062NR1H33
5108PCM13
9794MAML13
284656EPHA103
57523NYNRIN8
9874TLK13
28514DLL12
5834PYGB1
58508KMT2C8
6092ROBO23
4088SMAD33
27086FOXP14
79058ASPSCR12
4855NOTCH41
6794STK111
57194ATP10A3
4857NOVA19
25836NIPBL4
57410SCYL12
4292MLH11
54498SMOX2
2263FGFR24
4086SMAD11
2133EXT35
9639ARHGEF103
7249TSC22
1019CDK41
7409VAV12
11213IRAK32
9967THRAP32
863CBFA2T31
8874ARHGEF71
1555CYP2B64
55034MOCOS3
5600MAPK112
3572IL6ST2
5077PAX35
6197RPS6KA33
55589BMP2K6
65125WNK14
57591MRTFA1
136332LRGUK5
652BMP43
5650KLK72
7175TPR4
8997KALRN2
4437MSH33
6795AURKC3
2071ERCC33
3643INSR3
57551TAOK12
5610EIF2AK22
23469PHF32
4089SMAD44
170692ADAMTS182
6654SOS11
7204TRIO2
23373CRTC12
5727PTCH15
285220EPHA63
51366UBR56
3417IDH13
23678SGK33
10926DBF41
5578PRKCA5
4214MAP3K12
440275EIF2AK42
9972NUP1532
3239HOXD136
92335STRADA3
4293MAP3K94
26524LATS25
85366MYLK23
2318FLNC3
10565ARFGEF15
57154SMURF12
675BRCA27
7075TIE12
640BLK1
157680VPS13B5
2735GLI13
4609MYC3
8013NR4A33
10461MERTK2
51321AMZ25
7297TYK24
26278SACS2
894CCND21
283629TSSK43
5462POU5F1B1
1440CSF32
29951PDZRN42
51701NLK4
6446SGK13
79759ZNF6682
833CARS3
3635INPP5D1
7917BAG64
375056MIA33
93627TBCK1
3949LDLR1
7015TERT3
7153TOP2A1
57082KNL14
1981EIF4G13
1213CLTC3
84879MFSD2A3
1769DNAH82
22976PAXIP13
3315HSPB13
83452RAB33B2
5598MAPK74
8924HERC26
120892LRRK28
6095RORA11
29844TFPT2
84441MAML23
7301TYRO33
5205ATP8B12
8178ELL3
1024CDK82
7849PAX86
9321TRIP113
9451EIF2AK32
4853NOTCH26
9509ADAMTS21
23396PIP5K1C6
8312AXIN12
23476BRD43
5728PTEN2
5595MAPK32
7155TOP2B2
1869E2F13
22883CLSTN12
115701ALPK24
284086NEK81
5305PIP4K2A1
23542MAPK8IP22
352909DNAAF32
6770STAR3
2188FANCF3
2324FLT43
2648KAT2A2
3678ITGA53
7273TTN2
91807MYLK32
79834PEAK13
6789STK41
23332CLASP14
7059THBS32
79012CAMKV5
3161HMMR2
55561CDC42BPG5
2046EPHA83
8821INPP4B2
10243GPHN2
1662DDX102
23305ACSL63
344905ATP13A56
5588PRKCQ3
10076PTPRU7
7248TSC13
5923RASGRF13
2690GHR1
100124696TEC3
7094TLN11
5609MAP2K75
9659PDE4DIP2
3624INHBA3
5927KDM5A4
5587PRKD13
5583PRKCH3
2321FLT12
23139MAST22
22982DIP2C3
2157F81
5506PPP1R3A2
1627DBN13
6778STAT63
51562MBIP2
5932RBBP82
23512SUZ125
8536CAMK13
2122MECOM3
5925RB16
4217MAP3K53
1209CLPTM12
2065ERBB33
5324PLAG13
10420TESK24
2534FYN3
7508XPC3
55959SULF21
3716JAK12
79728PALB23
23092ARHGAP265
51135IRAK48
10494STK253
4915NTRK25
11086ADAM293
142PARP14
9262STK17B3
2261FGFR35
23072HECW12
2073ERCC53
55422ZNF3313
1013CDH152
3092HIP14
8321FZD13
4763NF13
57697FANCM2
63893UBE2O2
6886TAL12
94ACVRL12
2044EPHA52
4593MUSK1
4629MYH113
10048RANBP95
6868ADAM173
55193PBRM11
2178FANCE1
27255CNTN65
57699CPNE53
1499CTNNB14
2444FRK4
5602MAPK105
2892GRIA32
1436CSF1R3
1795DOCK32
2904GRIN2B4
5624PROC4
5970RELA4

Gene in drug-gene network: Network Plot

Models in GW843682X

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