iGMDRD318


Canonical SMILES: C=CCC1=CC=CC(=CNNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)C1=O

InChI: InChI=1S/C23H28N4O2/c1-2-7-20-10-6-11-21(23(20)29)16-24-25-22(28)18-27-14-12-26(13-15-27)17-19-8-4-3-5-9-19/h2-6,8-11,16,24H,1,7,12-15,17-18H2,(H,25,28)

InChI Key: XSGXRYNZNGUGEJ-UHFFFAOYSA-N

Standard NameCHEMBLPubchem CIDDrug StatusDrug Type
PAC-1CHEMBL591429 6753380AloneSmall Molecule


Drug Pathways:

Apoptosis regulation

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
331XIAP2
27125AFF41
4854NOTCH35
8999CDKL22
6664SOX116
7074TIAM12
997CDC343
79848CSPP12
7837PXDN7
10641NPRL21
21ABCA33
6581SLC22A32
132ADK8
3383ICAM15
6774STAT32
5933RBL12
6195RPS6KA11
7421VDR2
2986GUCY2F3
2048EPHB26
5546PRCC1
2956MSH63
2200FBN11
4303FOXO43
57679ALS23
150465TTL3
1520CTSS1
9149DYRK1B1
347365ITIH61
5295PIK3R11
55215FANCI6
8289ARID1A1
80070ADAMTS203
3939LDHA1
51231VRK33
11193WBP41
25778DSTYK3
2335FN19
4928NUP984
79092CARD143
53616ADAM223
9760TOX5
3431SP1104
2161F123
9263STK17A1
81035COLEC123
3326HSP90AB11
7764ZNF2172
10395DLC14
3069HDLBP3
3209HOXA131
6657SOX23
53944CSNK1G13
1786DNMT14
3320HSP90AA12
7253TSHR6
8749ADAM182
2241FER2
341676NEK51
5154PDGFA3
140469MYO3B2
604BCL61
7048TGFBR23
54822TRPM73
943TNFRSF81
577ADGRB34
1813DRD29
1387CREBBP2
10454TAB13
8844KSR12
2885GRB26
5788PTPRC3
23225NUP2102
56164STK314
5579PRKCB6
11200CHEK26
31ACACA1
10178TENM13
8558CDK104
26576SRPK31
5396PRRX11
5159PDGFRB5
7373COL14A15
5314PKHD13
51512GTSE13
139378ADGRG42
89910UBE3B2
974CD79B7
6927HNF1A2
54567DLL41
8784TNFRSF181
10746MAP3K23
23522KAT6B5
55728N4BP26
1453CSNK1D1
7852CXCR46
57670KIAA15493
22861NLRP12
837CASP41
440279UNC13C2
4610MYCL6
2115ETV12
10272FSTL31
84033OBSCN1
25937WWTR11
342977NANOS31
152137CCDC501
131096KCNH83
1880GPR1831
3621ING13
9693RAPGEF21
6418SET1
1586CYP17A13
3714JAG26
329BIRC22
4300MLLT31
8396PIP4K2B3
2242FES6
4005LMO21
22984PDCD115
8313AXIN22
6091ROBO12
2042EPHA33
1050CEBPA1
116986AGAP21
5330PLCB23
4216MAP3K43
6198RPS6KB11
1936EEF1D3
5601MAPK93
57761TRIB31
3303HSPA1A1
4194MDM43
27324TOX33
284217LAMA12
83931STK401
2045EPHA75
1992SERPINB16
1277COL1A12
375449MAST45
2064ERBB26
983CDK11
6850SYK6
57476GRAMD1B3
8643PTCH23
993CDC25A4
54899PXK2
29775CARD101
23387SIK33
4294MAP3K101
7525YES11
1452CSNK1A16
5286PIK3C2A1
6709SPTAN14
8215DVL1P13
50488MINK11
2068ERCC25
8859STK192
5568PRKACG3
6037RNASE31
9472AKAP63
3685ITGAV5
6917TCEA16
3667IRS18
80243PREX23
8945BTRC6
2580GAK2
139285AMER18
3418IDH23
8148TAF151
28996HIPK22
2521FUS3
3397ID11
4087SMAD21
9096TBX185
9564BCAR15
11344TWF26
8038ADAM122
6792CDKL52
54986ULK42
1123CHN12
1496CTNNA24
7010TEK3
5450POU2AF11
898CCNE11
2272FHIT4
2066ERBB43
904CCNT12
5327PLAT5
51517NCKIPSD4
1029CDKN2A1
139728PNCK6
9361LONP11
27436EML42
284656EPHA103
57523NYNRIN12
5336PLCG25
10018BCL2L111
27347STK392
3932LCK1
648BMI16
6794STK118
2322FLT32
960CD441
2329FMO48
356FASLG3
4292MLH11
54498SMOX1
84513PLPP56
130399ACVR1C2
225689MAPK153
5585PKN13
1019CDK43
7409VAV12
65243ZFP69B5
124540MSI23
85481PSKH23
5604MAP2K13
8874ARHGEF76
10516FBLN51
9088PKMYT13
7422VEGFA3
5164PDK21
369ARAF1
57105CYSLTR21
57591MRTFA5
7495XBP1P11
6934TCF7L21
4436MSH21
50945TBX221
652BMP41
6035RNASE13
6535SLC6A81
162979ZNF2961
5650KLK72
30012TLX31
5871MAP4K211
23365ARHGEF122
2081ERN13
84181CHD62
4026LPP1
8997KALRN6
4437MSH34
7994KAT6A6
3643INSR3
57111RAB251
23469PHF38
8288EPX3
6654SOS15
672BRCA15
11168PSIP13
835CASP21
5727PTCH18
285220EPHA65
546ATRX5
3426CFI3
2047EPHB12
7786MAP3K122
10926DBF46
64840PORCN1
57144PAK53
340533NEXMIF2
3702ITK2
440275EIF2AK42
9972NUP1533
50615IL21R1
84823LMNB23
5290PIK3CA1
1514CTSL3
4145MATK3
4293MAP3K93
253260RICTOR4
5045FURIN2
2318FLNC3
10565ARFGEF11
57154SMURF13
3458IFNG4
26166RGS225
607BCL92
10155TRIM283
1956EGFR1
8445DYRK25
640BLK2
157680VPS13B4
2735GLI13
3065HDAC14
64750SMURF22
3308HSPA46
5789PTPRD2
1326MAP3K86
5753PTK63
7297TYK25
896CCND32
29951PDZRN45
6776STAT5A1
5663PSEN13
5747PTK22
3635INPP5D1
8900CCNA14
23604DAPK21
7917BAG61
1544CYP1A29
93627TBCK7
56924PAK61
673BRAF1
1981EIF4G11
23532PRAME3
780DDR13
83452RAB33B2
57538ALPK33
6469SHH3
339345NANOS23
89795NAV32
79184BRCC32
6095RORA7
7301TYRO33
2113ETS12
5205ATP8B13
8029CUBN2
9113LATS12
8178ELL1
5979RET3
9321TRIP111
9451EIF2AK36
6615SNAI11
9509ADAMTS22
8621CDK136
23396PIP5K1C1
3654IRAK11
10010TANK4
8312AXIN15
10752CHL13
7030TFE34
100187828HBD6
22883CLSTN12
23281MTUS22
4004LMO11
3554IL1R12
23542MAPK8IP23
4317MMP81
6770STAR6
2188FANCF3
6146RPL223
6009RHEB3
2870GRK63
8301PICALM3
28954REM12
1445CSK4
8522GAS71
171023ASXL11
79834PEAK16
5582PRKCG2
995CDC25C4
6789STK42
2119ETV56
7454WAS2
7036TFR26
55356SLC22A153
2277VEGFD2
8667EIF3H2
54904NSD34
9372ZFYVE93
10249GLYAT4
3207HOXA111
10595ERN23
344905ATP13A52
5588PRKCQ3
4297KMT2A8
51151SLC45A22
5291PIK3CB5
1493CTLA43
10076PTPRU3
3985LIMK23
332BIRC52
317APAF11
2041EPHA11
2317FLNB3
9021SOCS33
778CACNA1F1
53353LRP1B5
3181HNRNPA2B13
152110NEK103
9659PDE4DIP1
9201DCLK11
4000LMNA1
2049EPHB33
283455KSR24
6093ROCK13
2130EWSR13
2776GNAQ2
131890GRK71
4628MYH105
55007FAM118A3
5589PRKCSH5
1975EIF4B3
57448BIRC66
57007ACKR33
5681PSKH11
3717JAK23
22982DIP2C5
7227TRPS13
5506PPP1R3A6
1627DBN12
6778STAT63
8899PRPF4B4
4067LYN2
8550MAPKAPK53
1030CDKN2B1
3984LIMK12
3516RBPJ2
80216ALPK11
5932RBBP82
3977LIFR1
330BIRC37
4261CIITA6
4330MN14
84072HORMAD11
1455CSNK1G21
444ASPH5
7046TGFBR12
2122MECOM2
3662IRF42
51167CYB5R410
1760DMPK1
5925RB14
7113TMPRSS21
1515CTSV3
4893NRAS1
7069THRSP1
63923TNN1
3691ITGB42
7508XPC2
2258FGF133
4302MLLT63
7040TGFB13
3488IGFBP51
2011MARK22
51135IRAK42
55869HDAC88
4299AFF12
9935MAFB1
142PARP18
374AREG3
2261FGFR31
8711TNK14
4040LRP64
1013CDH153
3092HIP12
4763NF13
8814CDKL11
1994ELAVL16
4613MYCN1
5288PIK3C2G4
2044EPHA55
5287PIK3C2B3
23031MAST36
30811HUNK1
3265HRAS1
4193MDM21
2178FANCE3
29110TBK11
5885RAD219
3895KTN11
27151CPAMD82
5602MAPK106
1436CSF1R3
167359NIM1K2
11035RIPK36
5970RELA1

Gene in drug-gene network: Network Plot

Models in PAC-1

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